Universität zu Köln

Umutesi, Justine ORCID: 0000-0001-9408-7685, Nsanzimana, Sabin, Liu, Carol Yingkai, Vanella, Patrizio, Ott, Joerdis J. and Krause, Gerard ORCID: 0000-0003-3328-8808 (2022). Long-term effect of chronic hepatitis B on mortality in HIV-infected persons in a differential HBV transmission setting. BMC Infect. Dis., 22 (1). LONDON: BMC. ISSN 1471-2334

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Abstract

Background There remain gaps in quantifying mortality risk among individuals co-infected with chronic hepatitis B (HBV) and human immunodeficiency virus (HIV) in sub-Saharan African contexts. Among a cohort of HIV-positive individuals in Rwanda, we estimate the difference in time-to mortality between HBV-positive (HIV/HBV co-infected) and HBV-negative (HIV mono-infected) individuals. Methods Using a dataset of HIV-infected adults screened for hepatitis B surface antigen (HBsAg) from January to June 2016 in Rwanda, we performed time-to-event analysis from the date of HBsAg results until death or end of study (31 December 2019). We used the Kaplan-Meier method to estimate probability of survival over time and Cox proportional hazard models to adjust for other factors associated with mortality. Results Of 21,105 available entries, 18,459 (87.5%) met the inclusion criteria. Mean age was 42.3 years (SD = 11.4) and 394 (2.1%) died during follow-up (mortality rate = 45.7 per 100,000 person-months, 95% confidence interval (CI) 41.4-50.4) Mortality rate ratio for co-infection was 1.7, 95% CI 1.1-2.6, however, Cox regression analysis did not show any association with mortality between compared groups. The adjusted analysis of covariates stratified by co-infection status showed that males, residing outside of the capital Kigali, drinking alcohol, WHO-HIV-clinical stage 3 and 4 were associated with increased mortality in this HIV cohort. Conclusions HBV infection does not significantly influence mortality among HIV-infected individuals in Rwanda. The current cohort is likely to have survived a period of high-risk exposure to HBV and HIV mortality and limited health care until their diagnosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Umutesi, Justine UNSPECIFIED orcid.org/0000-0001-9408-7685 UNSPECIFIED Nsanzimana, Sabin UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Carol Yingkai UNSPECIFIED UNSPECIFIED UNSPECIFIED Vanella, Patrizio UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Joerdis J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krause, Gerard UNSPECIFIED orcid.org/0000-0003-3328-8808 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687576
DOI:	10.1186/s12879-022-07477-1
Journal or Publication Title:	BMC Infect. Dis.
Volume:	22
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2334
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIRETROVIRAL THERAPY; VIRUS COINFECTION; INDIVIDUALS; AFRICA; PROGRESSION; PREVALENCE; PROGRAM; RWANDA; IMPACT; AIDS Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68757