Bschor, T., Bonnet, U., Pitzer, M., Baethge, C., Lieb, K., Gertz, H. -J. and Muller-Oerlinghausen, B. (2022). Stopping antidepressants: withdrawal symptoms and rebound effects Review and practical recommendations. Nervenarzt, 93 (1). S. 93 - 102. NEW YORK: SPRINGER. ISSN 1433-0407

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Abstract

Stopping antidepressants can cause withdrawal (discontinuation) symptoms, the return of the original illness, and rebound. The latter means that the disease will return stronger, faster, or with greater likelihood than if it had not been treated with medication. The Psychiatry Working Group of the Drug Commission of the German Medical Association (Akda) presents the scientific findings and provides practical recommendations for action. Withdrawal symptoms are multiform; unspecific physical symptoms are predominant. Distinguishing them from the recurrence of depressive symptoms can be difficult. Most of them are mild and self-limiting. There is insufficient evidence on the extent and frequency of rebound depression. The rebound risk implies that when establishing the medication, the short-term benefit must be weighed against the possible long-term risk of chronic depression or the possible need for long-term medication. Patients should be informed about the risk of withdrawal both as early as the joint decision-making process about treatment initiation and regularly during the course of treatment. Withdrawal should take place gradually, except in emergency situations, whereby small steps should be taken, especially in the low-dose range.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bschor, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonnet, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pitzer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baethge, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lieb, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gertz, H. -J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller-Oerlinghausen, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-687936
DOI: 10.1007/s00115-021-01243-5
Journal or Publication Title: Nervenarzt
Volume: 93
Number: 1
Page Range: S. 93 - 102
Date: 2022
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1433-0407
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DISCONTINUATIONMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68793

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