Universität zu Köln

Langenbach, Benedikt P., Kohl, Waldemar, Murai, Toshiya, Suslow, Thomas, Ohrmann, Patricia, Bauer, Jochen ORCID: 0000-0001-9345-2126, Matsukawa, Noriko, Son, Shuraku, Pedersen, Anya, Lichtenstein, Theresa, Miyata, Jun and Koelkebeck, Katja ORCID: 0000-0002-0469-3997 (2022). Cortical changes in patients with schizophrenia across two ethnic backgrounds. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

While it is known that cultural background influences the healthy brain, less is known about how it affects cortical changes in schizophrenia. Here, we tested whether schizophrenia differentially affected the brain in Japanese and German patients. In a sample of 155 patients with a diagnosis of schizophrenia and 191 healthy controls from Japan and Germany, we acquired 3 T-MRI of the brain. We subsequently compared cortical thickness and cortical surface area to identify whether differences between healthy controls and patients might be influenced by ethnicity. Additional analyses were performed to account for effects of duration of illness and medication. We found pronounced interactions between schizophrenia and cultural background in the cortical thickness of several areas, including the left inferior and middle temporal gyrus, as well as the right lateral occipital cortex. Regarding cortical surface area, interaction effects appeared in the insula and the occipital cortex, among others. Some of these brain areas are related to the expression of psychotic symptoms, which are known to differ across cultures. Our results indicate that cultural background impacts cortical structures in different ways, probably resulting in varying clinical manifestations, and call for the inclusion of more diverse samples in schizophrenia research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langenbach, Benedikt P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohl, Waldemar UNSPECIFIED UNSPECIFIED UNSPECIFIED Murai, Toshiya UNSPECIFIED UNSPECIFIED UNSPECIFIED Suslow, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohrmann, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jochen UNSPECIFIED orcid.org/0000-0001-9345-2126 UNSPECIFIED Matsukawa, Noriko UNSPECIFIED UNSPECIFIED UNSPECIFIED Son, Shuraku UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedersen, Anya UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenstein, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Miyata, Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED Koelkebeck, Katja UNSPECIFIED orcid.org/0000-0002-0469-3997 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-688036
DOI:	10.1038/s41598-022-14914-3
Journal or Publication Title:	Sci Rep
Volume:	12
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AUDITORY VERBAL HALLUCINATIONS; MATTER VOLUME; 1ST EPISODE; TEMPORAL GYRUS; THICKNESS; CULTURE; CORTEX; ABNORMALITIES; PSYCHOSIS; DURATION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68803