Universität zu Köln

Filser, Melanie, Buchner, Axel, Fink, Gereon Rudolf, Gold, Stefan M. and Penner, Iris-Katharina ORCID: 0000-0002-6746-1034 (2023). The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools. J. Neurol., 270 (1). S. 171 - 208. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

Introduction In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. Methods This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, anxiety, bipolar disorder, euphoria, and pseudobulbar affect. Furthermore, the association between affective symptoms and quality of life and the currently used diagnostic instruments for assessing these symptoms are considered whereby relevant studies published between 2009 and 2021 were included in the review. Results Patients with mild and moderate disability more frequently reported severe problems with depression and anxiety than severe mobility problems. Apart from the occurrence of depression, little is known about the association of other affective symptoms such as anxiety, bipolar disorder, euphoria, and pseudobulbar affect and subsyndromal symptoms, which fail to meet the diagnostic criteria but are nevertheless a significant source of distress. Although there are a few recommendations in the research to perform routine screenings for diagnosable affective disorders, a standardized diagnostic procedure to assess subsyndromal symptoms is still lacking. As the applied measurements are diverse and show low accuracy to detect these symptoms, patients who experience affective symptoms are less likely to be identified. Discussion In addition to the consideration of definite psychiatric diagnoses, there is an unmet need for a common definition and assessment of disease-related affective symptoms in MS. Future studies should focus on the improvement and standardization of a common diagnostic procedure for subsyndromal affective symptoms in MS to enable integrated and optimal care for patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Filser, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchner, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Gold, Stefan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Penner, Iris-Katharina UNSPECIFIED orcid.org/0000-0002-6746-1034 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689040
DOI:	10.1007/s00415-022-11359-6
Journal or Publication Title:	J. Neurol.
Volume:	270
Number:	1
Page Range:	S. 171 - 208
Date:	2023
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIPOLAR DISORDERS; MOOD DISORDERS; DEPRESSION; ANXIETY; BURDEN; MS; ASSOCIATION; COMORBIDITY; PREVALENCE; HEALTH Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68904