Universität zu Köln

Hoffmann, Christian, Hentrich, Marcus ORCID: 0000-0001-5622-348X, Tiemann, Markus, Rosenwald, Andreas, Weber, Florian ORCID: 0000-0001-7480-8828, Willenbacher, Wolfgang and Huebel, Kai (2022). Recent Advances in Castleman Disease. Oncol. Res. Treat., 45 (11). S. 693 - 705. BASEL: KARGER. ISSN 2296-5262

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Abstract

Background: Castleman disease (CD) encompasses a spectrum of rare disorders with characteristic histopathological features. Unicentric Castleman disease (UCD) is a benign, local hyperplasia of lymphoid tissue that is usually curable. Multicentric Castleman disease (MCD) manifests as a potentially life-threatening systemic disease with complex symptomatology which is mostly due to an overproduction of interleukin-6 (IL-6) or dysregulation of IL-6-related signaling pathways. From a therapeutic perspective, it is important to distinguish idiopathic MCD (iMCD) from those cases that are associated with the human herpes virus 8 (HHV-8+MCD). Summary: During recent years, it has become increasingly clear that even HHV-8-negative MCD is not a homogeneous entity and that there are clinically distinct variants. International consensus guidelines for diagnosis and treatment have been developed for iMCD and UCD. Key messages: We herein summarize recent advances in diagnosis, treatment and novel insights into the pathogenesis of this disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED orcid.org/0000-0001-5622-348X UNSPECIFIED Tiemann, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenwald, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Florian UNSPECIFIED orcid.org/0000-0001-7480-8828 UNSPECIFIED Willenbacher, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689210
DOI:	10.1159/000526640
Journal or Publication Title:	Oncol. Res. Treat.
Volume:	45
Number:	11
Page Range:	S. 693 - 705
Date:	2022
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	2296-5262
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPH-NODE HYPERPLASIA; TREATMENT GUIDELINES; DIAGNOSTIC-CRITERIA; CLINICAL-FEATURES; VIRAL LOAD; RITUXIMAB; CYTOKINE; INTERLEUKIN-6; SPECTRUM; SUBTYPE Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68921