Universität zu Köln

Lopez-Rivera, Javier A. A., Smuk, Victoria, Leu, Costin, Nasr, Gaelle, Vegh, Deborah, Stefanski, Arthur, Perez-Palma, Eduardo, Busch, Robyn, Jehi, Lara, Najm, Imad, Bluemcke, Ingmar and Lal, Dennis (2022). Incidence and prevalence of major epilepsy-associated brain lesions. Epilepsy Behav. Rep., 18. NEW YORK: ELSEVIER SCIENCE INC. ISSN 2589-9864

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Abstract

Epilepsy surgery is an effective treatment option for drug-resistant focal epilepsy patients with associ-ated structural brain lesions. However, little epidemiological data are available regarding the number of patients with these lesions. We reviewed data regarding (1) the prevalence and incidence of epilepsy; (2) the proportion of epilepsy patients with focal epilepsy, drug-resistant epilepsy, and drug-resistant focal epilepsies; and (3) the number of epilepsy presurgical evaluations and surgical resections. We also assessed the relative proportion of brain lesions using post-surgical histopathological findings from 541 surgical patients from the Cleveland Clinic and 9,523 patients from a European multi-center cohort. Data were combined to generate surgical candidate incidence and prevalence estimates and the first lesion-specific estimates for hippocampal sclerosis (HS), low-grade epilepsy-associated brain tumors (LEAT), malformations of cortical development (MCD), glial scars, vascular malformations, and encephalitis. The most frequently diagnosed brain lesions were HS (incidence = 2.32 +/- 0.26 in 100,000, prevalence = 19.40 +/- 2.16 in 100,000) for adults and MCD (incidence = 1.15 +/- 0.34 in 100,000, prevalence = 6.52 +/- 1.89 in 100,000) for children. Our estimates can guide patient advocacy groups, clin-icians, researchers, policymakers in education, development of health care strategy, resource allocation, and reimbursement schedules.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lopez-Rivera, Javier A. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smuk, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Leu, Costin UNSPECIFIED UNSPECIFIED UNSPECIFIED Nasr, Gaelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Vegh, Deborah UNSPECIFIED UNSPECIFIED UNSPECIFIED Stefanski, Arthur UNSPECIFIED UNSPECIFIED UNSPECIFIED Perez-Palma, Eduardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Busch, Robyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Jehi, Lara UNSPECIFIED UNSPECIFIED UNSPECIFIED Najm, Imad UNSPECIFIED UNSPECIFIED UNSPECIFIED Bluemcke, Ingmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Lal, Dennis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689556
DOI:	10.1016/j.ebr.2022.100527
Journal or Publication Title:	Epilepsy Behav. Rep.
Volume:	18
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	2589-9864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRUG-RESISTANT EPILEPSY; TASK-FORCE REPORT; REFRACTORY EPILEPSY; ADULT PATIENTS; ILAE COMMISSION; UNITED-STATES; CONSENSUS CLASSIFICATION; CORTICAL DYSPLASIAS; SEIZURE OUTCOMES; RISK-FACTORS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68955