Universität zu Köln

Reiter, Ursula M., Eckert, Alexander J., Dunstheimer, Desiree, Bechtold-Dalla Pozza, Susanne, Lullwitz, Caroline, Golembowski, Sven, Freff, Markus, Herrlinger, Silke, von Dem Berge, Thekla, Rehberg, Mirko, Lilienthal, Eggert and Holl, Reinhard W. (2022). Cataract in children and adolescents with type 1 diabetes. Insights from the German/Austrian DPV registry. Pediatr. Diabetes, 23 (3). S. 362 - 370. HOBOKEN: WILEY. ISSN 1399-5448

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Abstract

Objective To study diabetic cataract in type 1 diabetes in a large pediatric cohort. Methods The 92,633 patients aged 0.5-21 years from German/Austrian multicenter diabetes registry (DPV) were analyzed. The 235 patients (0.25%) with diabetic cataract were found, 200 could be categorized: 67 with early cataract (3 months before diabetes onset - 12 months afterwards), 133 with late cataract (>12 months after diabetes onset). Regression models adjusted for age and gender were used to compare clinical parameters at diabetes onset. Regression models for patients with late cataract were implemented for the total documentation period and additionally adjusted for diabetes duration. Results Rate of cataract development shows a peak at diabetes onset and declines with longer diabetes duration. Patients with cataract showed strong female preponderance. Patients developing early cataract were older at diabetes onset (12.8 years [11.8/13.9] vs. 8.9 [8.9/9.0]; p < 0.001) and showed higher HbA1c than patients without cataract (9.0% [8.55/9.38] vs. 7.6% [7.60/7.61]; p < 0.001). They had lower height-SDS, (-0.22 [-0.48/0.04] vs. 0.25 [0.24/0.26]; p < 0.001), lower weight-SDS (-0.31 [-0.55/-0.08] vs. 0.21 [0.20/0.21]; p < 0.001) and lower BMI-SDS (-0.25 [-0.49/-0.02] vs. 0.12 [0.12/0.13); p = 0.002). Patients with late cataract showed higher HbA1c at diabetes onset (8.35% [8.08/8.62] vs. 8.04% [8.03/8.05]; p = 0.023) and higher mean HbA1c during total documentation period (8.00% [7.62/8.34] vs. 7.62% [7.61/7.63]; p = 0.048). Conclusions Our data confirm known demographic and clinical characteristics of patients developing early cataract. Hyperglycemia-induced osmotic damage to lens fibers at diabetes onset might be the main pathomechanism. Long term glycemic control is associated with cataract development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reiter, Ursula M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckert, Alexander J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunstheimer, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechtold-Dalla Pozza, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Lullwitz, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Golembowski, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Freff, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrlinger, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED von Dem Berge, Thekla UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, Mirko UNSPECIFIED UNSPECIFIED UNSPECIFIED Lilienthal, Eggert UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689625
DOI:	10.1111/pedi.13316
Journal or Publication Title:	Pediatr. Diabetes
Volume:	23
Number:	3
Page Range:	S. 362 - 370
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-5448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METABOLIC CATARACTS; RISK-FACTORS; RETINOPATHY; SURGERY; GERMANY Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68962