Universität zu Köln

Jesinghaus, Moritz ORCID: 0000-0002-0018-5661, Herz, Anna-Lina, Kohlruss, Meike, Silva, Miguel ORCID: 0000-0002-2940-0732, Grass, Albert, Lange, Sebastian ORCID: 0000-0003-0406-1401, Novotny, Alexander, Ott, Katja, Schmidt, Thomas, Gaida, Matthias, Hapfelmeier, Alexander, Denkert, Carsten, Weichert, Wilko and Keller, Gisela (2022). Post-neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage- and regression-grade independent prognostic information in intestinal-type gastric adenocarcinoma. J. Pathol. Clin. Res., 8 (5). S. 448 - 458. HOBOKEN: WILEY. ISSN 2056-4538

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Abstract

Tumour budding (TB) has been associated with adverse clinicopathological factors and poor survival in a plethora of therapy-naive carcinoma entities including gastric adenocarcinoma (GC). As conventional histopathological grading is usually omitted in the post-neoadjuvant setting of GC, our study aimed to investigate the prognostic impact of TB in GCs resected after neoadjuvant therapy. We evaluated TB according to the criteria from the International Tumour Budding Consensus Conference (ITBCC) in 167 post-neoadjuvant resections of intestinaltype GC and correlated the results with overall survival (OS) and clinicopathological parameters. GCs were categorised into Bd1 (0-4 buds, low TB), Bd2 (5-9 buds, intermediate TB), and Bd3 (>= 10 buds, high TB). Carcinomas with intermediate and high TB were significantly enriched in higher ypTNM stages and strongly associated with reduced 5-year OS in univariable analyses (p < 0.001). In multivariable analyses including sex, age, resection status, UICC stage, and tumour regression grading, TB remained a stage-independent predictor of survival (p < 0.001, hazard ratio Bd2: 2.60, Bd3: 4.74). The assessment of TB according to the ITBCC criteria provides valuable prognostic information in the post-neoadjuvant setting of intestinal-type GC and may be a considerable substitute for the conventional grading system in GCs after neoadjuvant therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jesinghaus, Moritz UNSPECIFIED orcid.org/0000-0002-0018-5661 UNSPECIFIED Herz, Anna-Lina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohlruss, Meike UNSPECIFIED UNSPECIFIED UNSPECIFIED Silva, Miguel UNSPECIFIED orcid.org/0000-0002-2940-0732 UNSPECIFIED Grass, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Sebastian UNSPECIFIED orcid.org/0000-0003-0406-1401 UNSPECIFIED Novotny, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaida, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hapfelmeier, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Denkert, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Weichert, Wilko UNSPECIFIED UNSPECIFIED UNSPECIFIED Keller, Gisela UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689843
DOI:	10.1002/cjp2.284
Journal or Publication Title:	J. Pathol. Clin. Res.
Volume:	8
Number:	5
Page Range:	S. 448 - 458
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2056-4538
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; COLORECTAL-CANCER; NEST SIZE; CHEMOTHERAPY; SURVIVAL; THERAPY; CLASSIFICATION; TRANSITION; EXPRESSION; INVASION Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68984