Universität zu Köln

de Hesselle, Marie Louise, Borgmann, Stefan, Rieg, Siegbert, Vehreshild, Jorg Janne, Spinner, Christoph D., Koll, Carolin E. M. ORCID: 0000-0001-7940-3264, Hower, Martin ORCID: 0000-0001-5967-5238, Stecher, Melanie, Ebert, Daniel, Hanses, Frank and Schumann, Julia (2022). Invasiveness of Ventilation Therapy Is Associated to Prevalence of Secondary Bacterial and Fungal Infections in Critically Ill COVID-19 Patients. J. Clin. Med., 11 (17). BASEL: MDPI. ISSN 2077-0383

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Abstract

Superinfections are a fundamental critical care problem, and their significance in severe COVID-19 cases needs to be determined. This study analyzed data from the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort focusing on intensive care patients. A retrospective analysis of patient data from 840 cases of COVID-19 with critical courses demonstrated that co-infections were frequently present and were primarily of nosocomial origin. Furthermore, our analysis showed that invasive therapy procedures accompanied an increased risk for healthcare-associated infections. Non-ventilated ICU patients were rarely affected by secondary infections. The risk of infection, however, increased even when non-invasive ventilation was used. A further, significant increase in infection rates was seen with the use of invasive ventilation and even more so with extracorporeal membrane oxygenation (ECMO) therapy. The marked differences among ICU techniques used for the treatment of COVID-19-induced respiratory failure in terms of secondary infection risk profile should be taken into account for the optimal management of critically ill COVID-19 patients, as well as for adequate antimicrobial therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code de Hesselle, Marie Louise UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgmann, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieg, Siegbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreshild, Jorg Janne UNSPECIFIED UNSPECIFIED UNSPECIFIED Spinner, Christoph D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koll, Carolin E. M. UNSPECIFIED orcid.org/0000-0001-7940-3264 UNSPECIFIED Hower, Martin UNSPECIFIED orcid.org/0000-0001-5967-5238 UNSPECIFIED Stecher, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebert, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanses, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumann, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689862
DOI:	10.3390/jcm11175239
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	17
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COINFECTION; INFLUENZA; PATHOGENESIS; VIRUS; CARE Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68986