Universität zu Köln

Schiemenz, C., Lueken, S., Klassen, A. M., Ranjbar, M., Illerhaus, G., Fend, F., Heindl, L. M., Chronopoulos, A., Grisanti, S. and Kakkassery, V (2022). Clinical procedures for intraocular lymphomas. Ophthalmologie, 119 (7). S. 675 - 686. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-7218

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Abstract

Background The classification of intraocular lymphomas is based on their anatomical location. They are divided into uveal lymphomas with involvement of the choroid, ciliary body or iris and vitreoretinal lymphomas with isolated or combined involvement of the vitreous body and/or retina. Over the last decades it has become increasingly possible to work out the clinical and pathobiological features of the various subtypes, thereby reducing the diagnostic hurdles and creating improved treatment options. Objective A summary of the various types of intraocular lymphoma in terms of clinical features, diagnostics, treatment and prognosis is given as well as recommendations for follow-up care. Methods A selective literature search was carried out on the subject of intraocular lymphomas using PubMed and Google Scholar. Results Intraocular lymphomas affect different structures, so that the symptoms can also be very different. The diagnostic spectrum ranges from typical ocular examination methods to sample biopsies with subsequent cytological, histological and molecular pathological processing. The treatment pillars available are percutaneous irradiation and intravitreal drug administration as local treatment and systemic treatment or a combination of systemic and local treatment. The prognosis depends mainly on the subtype of the lymphoma and the extent of the infestation when the diagnosis is confirmed. Even though some effective treatment options are now available, it has not yet been possible to significantly reduce the mortality rate. Conclusion Many different options are available for the diagnostics and treatment of intraocular lymphomas, which require close interdisciplinary cooperation. The further developments in the field of molecular pathology allow a faster and more accurate diagnosis and could open up new treatment options in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schiemenz, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueken, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klassen, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ranjbar, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Illerhaus, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fend, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, L. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chronopoulos, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisanti, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kakkassery, V UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690123
DOI:	10.1007/s00347-022-01651-1
Journal or Publication Title:	Ophthalmologie
Volume:	119
Number:	7
Page Range:	S. 675 - 686
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-7218
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VITREORETINAL LYMPHOMA; OCULAR LYMPHOMA; TUMOR-BIOPSY; FEATURES; DIAGNOSTICS; IRIS; INVOLVEMENT; MYD88; CNS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69012