Universität zu Köln

Steidel, Kenan ORCID: 0000-0002-1556-3573, Ruppert, Marina C., Greuel, Andrea, Tahmasian, Masoud, Maier, Franziska ORCID: 0000-0002-9335-9594, Hammes, Jochen, van Eimeren, Thilo, Timmermann, Lars, Tittgemeyer, Marc, Drzezga, Alexander, Pedrosa, David J. ORCID: 0000-0002-5403-1959 and Eggers, Carsten (2022). Longitudinal trimodal imaging of midbrain-associated network degeneration in Parkinson's disease. npj Parkinsons Dis., 8 (1). BERLIN: NATURE PORTFOLIO. ISSN 2373-8057

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Abstract

The prevailing network perspective of Parkinson's disease (PD) emerges not least from the ascending neuropathology traceable in histological studies. However, whether longitudinal in vivo correlates of network degeneration in PD can be observed remains unresolved. Here, we applied a trimodal imaging protocol combining 18F-fluorodeoxyglucose (FDG)- and 18F-fluoro-L-Dopa- (FDOPA)-PET with resting-state functional MRI to assess longitudinal changes in midbrain metabolism, striatal dopamine depletion and striatocortical dysconnectivity in 17 well-characterized PD patients. Whole-brain (un)paired-t-tests with focus on midbrain or striatum were performed between visits and in relation to 14 healthy controls (HC) in PET modalities. Resulting clusters of FDOPA-PET comparisons provided volumes for seed-based functional connectivity (FC) analyses between visits and in relation to HC. FDG metabolism in the left midbrain decreased compared to baseline along with caudatal FDOPA-uptake. This caudate cluster exhibited a longitudinal FC decrease to sensorimotor and frontal areas. Compared to healthy subjects, dopamine-depleted putamina indicated stronger decline in striatocortical FC at follow-up with respect to baseline. Increasing nigrostriatal deficits and striatocortical decoupling were associated with deterioration in motor scores between visits in repeated-measures correlations. In summary, our results demonstrate the feasibility of in-vivo tracking of progressive network degeneration using a multimodal imaging approach. Specifically, our data suggest advancing striatal and widespread striatocortical dysfunction via an anterior-posterior gradient originating from a hypometabolic midbrain cluster within a well-characterized and only mild to moderately affected PD cohort during a relatively short period.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Steidel, Kenan UNSPECIFIED orcid.org/0000-0002-1556-3573 UNSPECIFIED Ruppert, Marina C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Greuel, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Tahmasian, Masoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED orcid.org/0000-0002-9335-9594 UNSPECIFIED Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedrosa, David J. UNSPECIFIED orcid.org/0000-0002-5403-1959 UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690362
DOI:	10.1038/s41531-022-00341-8
Journal or Publication Title:	npj Parkinsons Dis.
Volume:	8
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2373-8057
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATE FUNCTIONAL CONNECTIVITY; POSITRON-EMISSION-TOMOGRAPHY; METABOLIC BRAIN NETWORKS; COGNITIVE DECLINE; SUBSTANTIA-NIGRA; DYSFUNCTION; STRIATUM; PATTERNS; PROGRESSION; VALIDATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69036