Universität zu Köln

van de Klundert, Maarten A. A., Antonova, Anastasiia, Di Teodoro, Giulia, Diez, Rafael Cena, Chkhartishvili, Nikoloz, Heger, Eva, Kuznetsova, Anna, Lebedev, Aleksey, Narayanan, Aswathy, Ozhmegova, Ekaterina ORCID: 0000-0002-3110-0843, Pronin, Alexander, Shemshura, Andrey ORCID: 0000-0003-1637-4229, Tumanov, Alexandr, Pfeifer, Nico, Kaiser, Rolf, Saladini, Francesco ORCID: 0000-0002-9934-377X, Zazzi, Maurizio ORCID: 0000-0002-0344-6281, Incardona, Francesca, Bobkova, Marina ORCID: 0000-0001-5481-8957 and Sonnerborg, Anders (2022). Molecular Epidemiology of HIV-1 in Eastern Europe and Russia. Viruses-Basel, 14 (10). BASEL: MDPI. ISSN 1999-4915

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Abstract

The HIV epidemic in Eastern Europe and Russia is large and not well-controlled. To describe the more recent molecular epidemiology of HIV-1, transmitted drug resistance, and the relationship between the epidemics in this region, we sequenced the protease and reverse transcriptase genes of HIV-1 from 812 people living with HIV from Ukraine (n = 191), Georgia (n = 201), and Russia (n = 420) before the initiation of antiretroviral therapy. In 190 Ukrainian patients, the integrase gene sequence was also determined. The most reported route of transmission was heterosexual contact, followed by intravenous drug use, and men having sex with men (MSM). Several pre-existing drug resistance mutations were found against non-nucleoside reverse transcriptase inhibitors (RTIs) (n = 103), protease inhibitors (n = 11), and nucleoside analogue RTIs (n = 12), mostly polymorphic mutations or revertants. In the integrase gene, four strains with accessory integrase strand transfer inhibitor mutations were identified. Sub-subtype A6 caused most of the infections (713/812; 87.8%) in all three countries, including in MSM. In contrast to earlier studies, no clear clusters related to the route of transmission were identified, indicating that, within the region, the exchange of viruses among the different risk groups may occur more often than earlier reported.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van de Klundert, Maarten A. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonova, Anastasiia UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Teodoro, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Diez, Rafael Cena UNSPECIFIED UNSPECIFIED UNSPECIFIED Chkhartishvili, Nikoloz UNSPECIFIED UNSPECIFIED UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuznetsova, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Lebedev, Aleksey UNSPECIFIED UNSPECIFIED UNSPECIFIED Narayanan, Aswathy UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozhmegova, Ekaterina UNSPECIFIED orcid.org/0000-0002-3110-0843 UNSPECIFIED Pronin, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Shemshura, Andrey UNSPECIFIED orcid.org/0000-0003-1637-4229 UNSPECIFIED Tumanov, Alexandr UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Saladini, Francesco UNSPECIFIED orcid.org/0000-0002-9934-377X UNSPECIFIED Zazzi, Maurizio UNSPECIFIED orcid.org/0000-0002-0344-6281 UNSPECIFIED Incardona, Francesca UNSPECIFIED UNSPECIFIED UNSPECIFIED Bobkova, Marina UNSPECIFIED orcid.org/0000-0001-5481-8957 UNSPECIFIED Sonnerborg, Anders UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690736
DOI:	10.3390/v14102099
Journal or Publication Title:	Viruses-Basel
Volume:	14
Number:	10
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1999-4915
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE; SUBTYPE; CABOTEGRAVIR; RECOMBINANT; RILPIVIRINE; PROTEASE; PROGRAM; JPHMM Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69073