Universität zu Köln

Thiele, Jurgen, Kvasnicka, Hans Michael, Orazi, Attilio, Gianelli, Umberto, Gangat, Naseema, Vannucchi, Alessandro M., Barbui, Tiziano, Arber, Daniel A. and Tefferi, Ayalew (2023). The international consensus classification of myeloid neoplasms and acute Leukemias: myeloproliferative neoplasms. Am. J. Hematol., 98 (1). S. 166 - 180. HOBOKEN: WILEY. ISSN 1096-8652

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Abstract

A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group introduced the new International Consensus Classification (ICC) for Myeloid Neoplasms and Acute Leukemias. This current in-depth review focuses on the ICC-2022 category of JAK2 mutation-prevalent myeloproliferative neoplasms (MPNs): essential thrombocythemia, polycythemia vera, primary myelofibrosis, and MPN, unclassifiable. The ICC MPN subcommittee chose to preserve the primary role of bone marrow morphology in disease classification and diagnostics, while also acknowledging the complementary role of genetic markers for establishing clonality, facilitating MPN subtype designation, and disease prognostication.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thiele, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kvasnicka, Hans Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Orazi, Attilio UNSPECIFIED UNSPECIFIED UNSPECIFIED Gianelli, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Gangat, Naseema UNSPECIFIED UNSPECIFIED UNSPECIFIED Vannucchi, Alessandro M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbui, Tiziano UNSPECIFIED UNSPECIFIED UNSPECIFIED Arber, Daniel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tefferi, Ayalew UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690796
DOI:	10.1002/ajh.26751
Journal or Publication Title:	Am. J. Hematol.
Volume:	98
Number:	1
Page Range:	S. 166 - 180
Date:	2023
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1096-8652
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MARROW FIBROSIS; WORLD-HEALTH-ORGANIZATION; MASKED POLYCYTHEMIA-VERA; EARLY PRIMARY MYELOFIBROSIS; ESSENTIAL THROMBOCYTHEMIA; DIAGNOSTIC-CRITERIA; EUROPEAN CONSENSUS; CYTOGENETIC ABNORMALITIES; VENOUS THROMBOSIS; PROGNOSTIC SCORE Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69079