Universität zu Köln

Yogev, Nir, Bedke, Tanja, Kobayashi, Yasushi, Brockmann, Leonie, Lukas, Dominika, Regen, Tommy ORCID: 0000-0002-7275-3330, Croxford, Andrew L., Nikolav, Alexei, Hovelmeyer, Nadine, von Stebut, Esther, Prinz, Marco, Ubeda, Carles ORCID: 0000-0003-0560-4658, Maloy, Kevin J., Gagliani, Nicola ORCID: 0000-0001-8514-1395, Flavell, Richard A., Waisman, Ari and Huber, Samuel ORCID: 0000-0001-9325-8227 (2022). CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. Cell Reports, 38 (13). CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, significantly contributing to the maintenance and reestablishment of immune homeostasis. Accordingly, it has been shown in the intestine that IL-10 produced by Tregs can act on effector T cells, thereby limiting inflammation. Herein, we investigate whether this role also applies to IL-10 produced by T cells during central nervous system (CNS) inflammation. During neuroinflammation, both CNS-resident and-infiltrating cells produce IL-10; yet, as IL-10 has a pleotropic function, the exact contribution of the different cellular sources is not fully understood. We find that T-cell-derived IL-10, but not other relevant IL-10 sources, can promote inflammation in experimental autoimmune encephalomyelitis. Furthermore, in the CNS, T-cell-derived IL-10 acts on effector T cells, promoting their survival and thereby enhancing inflammation and CNS autoimmunity. Our data indicate a pro -inflammatory role of T-cell-derived IL-10 in the CNS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yogev, Nir UNSPECIFIED UNSPECIFIED UNSPECIFIED Bedke, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobayashi, Yasushi UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lukas, Dominika UNSPECIFIED UNSPECIFIED UNSPECIFIED Regen, Tommy UNSPECIFIED orcid.org/0000-0002-7275-3330 UNSPECIFIED Croxford, Andrew L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nikolav, Alexei UNSPECIFIED UNSPECIFIED UNSPECIFIED Hovelmeyer, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Prinz, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Ubeda, Carles UNSPECIFIED orcid.org/0000-0003-0560-4658 UNSPECIFIED Maloy, Kevin J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gagliani, Nicola UNSPECIFIED orcid.org/0000-0001-8514-1395 UNSPECIFIED Flavell, Richard A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Waisman, Ari UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, Samuel UNSPECIFIED orcid.org/0000-0001-9325-8227 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690900
DOI:	10.1016/j.celrep.2022.110565
Journal or Publication Title:	Cell Reports
Volume:	38
Number:	13
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; INTERLEUKIN-10 RECEPTOR; B-CELLS; RESPONSES; CYTOKINE; GENE; POLYMORPHISMS; ASSOCIATION; RESOLUTION; EXPRESSION Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69090