Universität zu Köln

Haarmann, Lena, Kalbe, Elke, Lewis, Catharine J., Eggers, Carsten, Kuehn, Andrea A., Krug, Henriette ORCID: 0000-0001-6562-6635, Volkmann, Jens, Kirsch, Anna D., Wojtecki, Lars, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Deuschl, Guenther, Krauss, Joachim K., Woopen, Christiane, Timmermann, Lars and Maier, Franziska ORCID: 0000-0002-9335-9594 (2022). The Deep Brain Stimulation Impairment Scale: A useful complement in assessment of well-being and functioning in DBS-patients - Results from a large multicentre survey in patients with Parkinson's disease. Parkinsonism Relat. Disord., 99. S. 8 - 16. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Background: Deep Brain Stimulation (DBS) has been proven to alleviate motor symptoms in Parkinson's Disease (PD). Regarding non-motor symptoms, however, inconsistencies have been reported, on whether DBS causes reductions in well-being and functioning. To assess motor and non-motor impairment in DBS-patients, the Deep Brain Stimulation Impairment Scale (DBS-IS) has been developed. Yet, the extent to which the DBS-IS detects impairment in DBS-patients and thus could serve as a useful tool that complements the PDQ-39 (gold standard) in assessment of well-being and functioning in PD-patients has not been shown. Objectives: By comparing DBS and non-DBS-patients we aimed to identify DBS-specific symptoms. We thereby aimed to show in how far the DBS-IS complements the PDQ-39 in assessing well-being and functioning in PD patients under DBS. Methods: In a cross-sectional study, 186 DBS-patients were matched (for age, disease duration and sex) to 186 non-DBS-patients (N = 372) and the two groups were compared regarding well-being and functioning: Impairment was assessed via DBS-IS and overall Quality of Life (QoL) was assessed via PDQ-39. Additionally, we analyzed differences in impairment between age and disease duration clusters. Results: DBS-patients showed significantly higher total impairment (DBS-IS) and significantly higher impairment on the subscales Postural Instability and Gait difficulties and speaking difficulties than non-DBS-patients. Impairment increased with age and disease duration and, overall, differences in impairment rose by age. Overall QoL (PDQ-39) was non-significantly lower in DBS-patients. Conclusion: Since there is evidence that the PDQ-39 misses some DBS-specific symptoms, the DBS-IS is recom-mended to complement the PDQ-39 when assessing DBS-patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haarmann, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Catharine J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehn, Andrea A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Henriette UNSPECIFIED orcid.org/0000-0001-6562-6635 UNSPECIFIED Volkmann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirsch, Anna D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojtecki, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Alfons UNSPECIFIED orcid.org/0000-0002-6414-7939 UNSPECIFIED Deuschl, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauss, Joachim K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woopen, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED orcid.org/0000-0002-9335-9594 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691307
DOI:	10.1016/j.parkreldis.2022.04.008
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	99
Page Range:	S. 8 - 16
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; SUBTHALAMIC NUCLEUS; RANDOMIZED-TRIAL; VALIDATION; INVENTORY; APATHY Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69130