Universität zu Köln

Zampino, Marta, Polidori, M. Cristina, Ferrucci, Luigi, O'Neill, Desmond ORCID: 0000-0002-5542-9897, Pilotto, Alberto, Gogol, Manfred and Rubenstein, Laurence (2022). Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment. GeroScience, 44 (6). S. 2611 - 2623. DORDRECHT: SPRINGER. ISSN 2509-2723

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Abstract

Measuring intrinsic, biological age is a central question in medicine, which scientists have been trying to answer for decades. Age manifests itself differently in different individuals, and chronological age often does not reflect such heterogeneity of health and function. We discuss here the value of measuring age and aging using the comprehensive geriatric assessment (CGA), cornerstone of geriatric medicine, and operationalized assessment tools for prognosis. Specifically, we review the benefits of employing the multidimensional prognostic index (MPI), which collects information about eight domains relevant for the global assessment of the older person (functional and cognitive status, nutrition, mobility and risk of pressure sores, multi-morbidity, polypharmacy, and co-habitation), in the evaluation of the functional status, and in the prediction of health outcomes for older adults. Further integration of biological markers of aging into multidimensional prognostic tools is warranted, as well as actions which could facilitate prognostic assessments for older persons in all healthcare settings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zampino, Marta UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, M. Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrucci, Luigi UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Neill, Desmond UNSPECIFIED orcid.org/0000-0002-5542-9897 UNSPECIFIED Pilotto, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Gogol, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubenstein, Laurence UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691373
DOI:	10.1007/s11357-022-00613-4
Journal or Publication Title:	GeroScience
Volume:	44
Number:	6
Page Range:	S. 2611 - 2623
Date:	2022
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	2509-2723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTIDIMENSIONAL PROGNOSTIC INDEX; COMMUNITY-ACQUIRED PNEUMONIA; FRAIL OLDER PATIENTS; ALL-CAUSE MORTALITY; LENGTH-OF-STAY; CLINICAL-PRACTICE; TERM MORTALITY; ASSESSMENT CGA; ADULTS; OUTCOMES Multiple languages Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69137