Universität zu Köln

Bredart, Anne, Kop, Jean-Luc ORCID: 0000-0002-6963-8411, Tuchler, Anja ORCID: 0000-0001-9985-8397, De Pauw, Antoine, Cano, Alejandra, Dick, Julia, Rhiem, Kerstin, Devilee, Peter, Schmutzler, Rita, Stoppa-Lyonnet, Dominique ORCID: 0000-0002-5438-8309 and Dolbeault, Sylvie (2022). Assessment of psychosocial difficulties by genetic clinicians and distress in women at high risk of breast cancer: a prospective study. Eur. J. Hum. Genet., 30 (9). S. 1067 - 1076. LONDON: SPRINGERNATURE. ISSN 1476-5438

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Abstract

We examined how often genetic clinicians correctly identify psychosocial difficulties in women at high breast cancer risk and explored effects of this assessment and the genetic test result on counselees' distress. A prospective observational study of counselee-clinician dyads was performed in three French, German and Spanish genetic clinics, involving 709 counselees (participation rate, 83.4%) and 31 clinicians (participation rate, 100%). Counselee-clinician agreement in perceived psychosocial difficulties was measured after the pre-test genetic consultation. Multivariate mixed linear models accounting for clinicians were tested. Predicted distress levels were assessed after the pre- (T1) and post-test result disclosure consultations (T2). Depending on the difficulty domain, clinicians adequately assessed the presence or absence of difficulties in 51% (familial issues) to 59% (emotions) of counselees. When counselees' and clinicians' perceptions disagreed, difficulties were generally underestimated by clinicians. Counselees' distress levels remained stable from T1 to T2, irrespective of clinicians' appraisal adequacy, and the genetic test result disclosure. Psychological referral need were found in 20-42% of counselees, more frequently observed for difficulties in the emotions domain. Our findings suggest that the genetic test result is a suboptimal indicator for psychological referral. Instead, clinicians should focus on emotions expressed by counselees to appraise their needs for psychological support.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bredart, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kop, Jean-Luc UNSPECIFIED orcid.org/0000-0002-6963-8411 UNSPECIFIED Tuchler, Anja UNSPECIFIED orcid.org/0000-0001-9985-8397 UNSPECIFIED De Pauw, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Cano, Alejandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Dick, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Devilee, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoppa-Lyonnet, Dominique UNSPECIFIED orcid.org/0000-0002-5438-8309 UNSPECIFIED Dolbeault, Sylvie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691695
DOI:	10.1038/s41431-022-01096-9
Journal or Publication Title:	Eur. J. Hum. Genet.
Volume:	30
Number:	9
Page Range:	S. 1067 - 1076
Date:	2022
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5438
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRCA1/2 TEST RESULT; PSYCHOLOGICAL IMPACT; HEREDITARY BREAST; HOSPITAL ANXIETY; COMMUNICATION; ONCOLOGISTS; DEPRESSION; GUIDELINES Multiple languages Biochemistry & Molecular Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69169