Universität zu Köln

Mulorz, Joscha, Spin, Joshua M., Mulorz, Pireyatharsheny, Wagenhaeuser, Markus, Deng, Alicia, Mattern, Karin, Rhee, Yae H., Toyama, Kensuke, Adam, Matti, Schelzig, Hubert, Maegdefessel, Lars and Tsao, Philip S. . E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1. Cardiovasc. Res.. OXFORD: OXFORD UNIV PRESS. ISSN 1755-3245

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Abstract

Aims Abdominal aortic aneurysm (AAA) is a common cardiovascular disease with a strong correlation to smoking, although underlying mechanisms have been minimally explored. Electronic cigarettes (e-cigs) have gained recent broad popularity and can deliver nicotine at comparable levels to tobacco cigarettes, but effects on AAA development are unknown. Methods and results We evaluated the impact of daily e-cig vaping with nicotine on AAA using two complementary murine models and found that exposure enhanced aneurysm development in both models and genders. E-cigs induced changes in key mediators of AAA development including cytokine chitinase-3-like protein 1 (CHI3L1/Chil1) and its targeting microRNA-24 (miR-24). We show that nicotine triggers inflammatory signalling and reactive oxygen species while modulating miR-24 and CHI3L1/Chil1 in vitro and that Chill is crucial to e-cig-augmented aneurysm formation using a knockout model. Conclusions In conclusion our work shows increased aneurysm formation along with augmented vascular inflammation in response to e-cig exposure with nicotine. Further, we identify Chill as a key mediator in this context. Our data raise concerns regarding the potentially harmful long-term effects of e-cig nicotine vaping. [GRAPHICS] .

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mulorz, Joscha UNSPECIFIED UNSPECIFIED UNSPECIFIED Spin, Joshua M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulorz, Pireyatharsheny UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagenhaeuser, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Deng, Alicia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mattern, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhee, Yae H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toyama, Kensuke UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, Matti UNSPECIFIED UNSPECIFIED UNSPECIFIED Schelzig, Hubert UNSPECIFIED UNSPECIFIED UNSPECIFIED Maegdefessel, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsao, Philip S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692213
DOI:	10.1093/cvr/cvac173
Journal or Publication Title:	Cardiovasc. Res.
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1755-3245
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ELECTRONIC CIGARETTES; OXIDATIVE STRESS; CHITINASE FAMILY; MOUSE MODEL; SMOKING; PROTEIN; ASSOCIATION; GENE; ATHEROSCLEROSIS; ACTIVATION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69221