Heinzel, Alexander, Dedic, Daniela, Galldiks, Norbert, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Stoffels, Gabriele, Filss, Christian P., Kocher, Martin, Migliorini, Filippo ORCID: 0000-0001-7220-1221, Dillen, Kim N. H., Geisler, Stefanie, Stegmayr, Carina, Willuweit, Antje, Sabel, Michael ORCID: 0009-0000-1485-7820, Rapp, Marion, Eble, Michael J., Piroth, Marc, Clusmann, Hans, Delev, Daniel, Bauer, Elena K., Ceccon, Garry, Dunkl, Veronika, Rosen, Jurij, Tscherpel, Caroline, Werner, Jan-Michael, Ruge, Maximilian I., Goldbrunner, Roland, Hampl, Jurgen, Weiss Lucas, Carolin, Herrlinger, Ulrich, Maurer, Gabriele D., Steinbach, Joachim P., Mauler, Joerg, Worthoff, Wieland A., Neumaier, Bernd N., Lerche, Christoph, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Shah, Nadim Jon, Mottaghy, Felix M. and Langen, Karl-Josef (2022). Two Decades of Brain Tumour Imaging with O-(2-[F-18]fluoroethyl)-L-tyrosine PET: The Forschungszentrum Julich Experience. Cancers, 14 (14). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary PET using radiolabelled amino acids has become an essential tool for diagnosing brain tumours in addition to MRI. O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) is one of the most successful tracers in the field. We analysed our database of 6534 FET PET examinations regarding the diagnostic needs and preferences of the referring physicians for FET PET in the clinical decision-making process. The demand for FET PET increased considerably in the last decade, especially for differentiating tumour progress from treatment-related changes in gliomas. Accordingly, referring physicians rated the diagnostics of recurrent glioma and recurrent brain metastases as the most relevant indication for FET PET. The analysis and survey results confirm the high relevance of FET PET in the clinical diagnosis of brain tumours and support the need for approval for routine use. O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) is a widely used amino acid tracer for positron emission tomography (PET) imaging of brain tumours. This retrospective study and survey aimed to analyse our extensive database regarding the development of FET PET investigations, indications, and the referring physicians' rating concerning the role of FET PET in the clinical decision-making process. Between 2006 and 2019, we performed 6534 FET PET scans on 3928 different patients against a backdrop of growing demand for FET PET. In 2019, indications for the use of FET PET were as follows: suspected recurrent glioma (46%), unclear brain lesions (20%), treatment monitoring (19%), and suspected recurrent brain metastasis (13%). The referring physicians were neurosurgeons (60%), neurologists (19%), radiation oncologists (11%), general oncologists (3%), and other physicians (7%). Most patients travelled 50 to 75 km, but 9% travelled more than 200 km. The role of FET PET in decision-making in clinical practice was evaluated by a questionnaire consisting of 30 questions, which was filled out by 23 referring physicians with long experience in FET PET. Fifty to seventy per cent rated FET PET as being important for different aspects of the assessment of newly diagnosed gliomas, including differential diagnosis, delineation of tumour extent for biopsy guidance, and treatment planning such as surgery or radiotherapy, 95% for the diagnosis of recurrent glioma, and 68% for the diagnosis of recurrent brain metastases. Approximately 50% of the referring physicians rated FET PET as necessary for treatment monitoring in patients with glioma or brain metastases. All referring physicians stated that the availability of FET PET is essential and that it should be approved for routine use. Although the present analysis is limited by the fact that only physicians who frequently referred patients for FET PET participated in the survey, the results confirm the high relevance of FET PET in the clinical diagnosis of brain tumours and support the need for its approval for routine use.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heinzel, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dedic, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galldiks, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohmann, PhilippUNSPECIFIEDorcid.org/0000-0002-5360-046XUNSPECIFIED
Stoffels, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Filss, Christian P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kocher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Migliorini, FilippoUNSPECIFIEDorcid.org/0000-0001-7220-1221UNSPECIFIED
Dillen, Kim N. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geisler, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stegmayr, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willuweit, AntjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabel, MichaelUNSPECIFIEDorcid.org/0009-0000-1485-7820UNSPECIFIED
Rapp, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eble, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piroth, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clusmann, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delev, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, Elena K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ceccon, GarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunkl, VeronikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosen, JurijUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tscherpel, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, Jan-MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruge, Maximilian I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldbrunner, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampl, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss Lucas, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrlinger, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maurer, Gabriele D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinbach, Joachim P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauler, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worthoff, Wieland A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, Bernd N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lerche, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Shah, Nadim JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mottaghy, Felix M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langen, Karl-JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-692577
DOI: 10.3390/cancers14143336
Journal or Publication Title: Cancers
Volume: 14
Number: 14
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6694
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITRON-EMISSION-TOMOGRAPHY; F-18-FET PET; GLIOMAS; MRI; DIAGNOSISMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69257

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