Jessen, Frank, Wolfsgruber, Steffen, Kleineindam, Luca, Spottke, Annika, Altenstein, Slawek ORCID: 0000-0003-2753-5999, Bartels, Claudia, Berger, Moritz, Brosseron, Frederic, Daamen, Marcel ORCID: 0000-0002-3017-3901, Dichgans, Martin ORCID: 0000-0002-0654-387X, Dobisch, Laura, Ewers, Michael, Fenski, Friederike, Fliessbach, Klaus, Freiesleben, Silka D., Glanz, Wenzel, Goerss, Doreen, Guersel, Selim, Janowitz, Daniel, Kilimann, Ingo, Kobeleva, Xenia, Lohse, Andrea, Maier, Franziska ORCID: 0000-0002-9335-9594, Metzger, Coraline, Munk, Matthias, Preis, Lukas ORCID: 0000-0001-7601-6410, Sanzenbacher, Carolin, Spruth, Eike, Rauchmann, Boris, Vukovich, Ruth, Yakupov, Renat, Weyrauch, Anne-Sophie, Ziegler, Gabriel, Schmid, Matthias ORCID: 0000-0002-0788-0317, Laske, Christoph, Perneczky, Robert, Schneider, Anja ORCID: 0000-0001-9540-8700, Wiltfang, Jens, Teipel, Stefan, Buerger, Katharina, Priller, Josef, Peters, Oliver ORCID: 0000-0003-0568-2998, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Boecker, Henning, Heneka, Michael T., Wagner, Michael and Duezel, Emrah . Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of the initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum. Methods Cross-sectional and longitudinal data from the multicenter, memory clinic-based DELCODE study. Results The SCD group showed slightly worse cognition as well as more subtle functional and behavioral symptoms than the control group (CO). SCD-A+ cases (39.3% of all SCD) showed greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms than CO-A+. Amyloid concentration in the CSF had a greater effect on longitudinal cognitive decline in SCD than in the CO group. Discussion Our data suggests that SCD serves the identification of stage 2 of the AD continuum and that stage 2, operationalized as SCD-A+, is associated with subtle, but extended impact of AD pathology in terms of neurodegeneration, symptoms and clinical progression.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineindam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenstein, SlawekUNSPECIFIEDorcid.org/0000-0003-2753-5999UNSPECIFIED
Bartels, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daamen, MarcelUNSPECIFIEDorcid.org/0000-0002-3017-3901UNSPECIFIED
Dichgans, MartinUNSPECIFIEDorcid.org/0000-0002-0654-387XUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewers, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fenski, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freiesleben, Silka D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glanz, WenzelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goerss, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guersel, SelimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobeleva, XeniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohse, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, FranziskaUNSPECIFIEDorcid.org/0000-0002-9335-9594UNSPECIFIED
Metzger, CoralineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munk, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preis, LukasUNSPECIFIEDorcid.org/0000-0001-7601-6410UNSPECIFIED
Sanzenbacher, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, EikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauchmann, BorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vukovich, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakupov, RenatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyrauch, Anne-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, GabrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmid, MatthiasUNSPECIFIEDorcid.org/0000-0002-0788-0317UNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perneczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDorcid.org/0000-0003-0568-2998UNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Boecker, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-692891
DOI: 10.1002/alz.12674
Journal or Publication Title: Alzheimers. Dement.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; IMPAIRMENT; DEMENTIA; RISK; RECOMMENDATIONS; SEGMENTATION; PROGRESSION; FRAMEWORKMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69289

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