Universität zu Köln

Gerards, Michelle, Schild, Ann-Katrin ORCID: 0000-0002-1920-0198, Meiberth, Dix, Rostamzadeh, Ayda ORCID: 0000-0001-5189-134X, Vehreschild, Jorg Janne ORCID: 0000-0002-5446-7170, Wingen-Heimann, Sebastian, Johannis, Wibke ORCID: 0000-0002-2886-7306, Adami, Pamela Martino, Onur, Oezguer A., Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Karikari, Thomas K., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Maier, Franziska ORCID: 0000-0002-9335-9594 and Jessen, Frank (2022). Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic Patients. Dement. Geriatr. Cogn. Disord., 51 (2). S. 182 - 193. BASEL: KARGER. ISSN 1421-9824

Full text not available from this repository.

Abstract

Introduction: Several recent research studies show high performance of blood biomarkers to identify Alzheimer's disease also in the pre-dementia mild cognitive impairment (MCI) stage, but data from the routine clinical care memory clinic setting are needed. Methods: We examined plasma samples of 144 memory clinic patients, including dementia of Alzheimer type (DAT, n = 54), MCI (n = 57), and subjective cognitive decline (SCD, n = 33), who either presented as self-referrals or were referred by general practitioners or neurologists or psychiatrists. The plasma biomarkers, amyloid-beta42 (Ass42), amyloid-beta40 (Ass40), phospho-Tau181 (pTau181), total-tau (tTau), and neurofilament light (NFL), as well as different ratios, were measured using the ultrasensitive single molecule array (Simoa) immunoassay technology. Statistical analysis including Kruskal-Wallis test, linear regression, and receiver operating characteristics analyses was performed. Results: Of the single markers, we observed statistically significant group effects of pTau181 (H(2) = 34.43, p < 0.001) and NFL (H(2) = 27.66, p < 0.001). All individual group comparisons of pTau181 were significant, while the contrast of SCD versus MCI for NFL was not significant. In addition, the ratios of Ass42/Ass40 (H(2) = 7.50, p = 0.02) and pTau181/Ass42 (H(2) = 25.26, p < 0.001) showed significant group effects with significant difference between all groups for pTau181/Ass42 and an SCD versus MCI difference for Ass42/Ass40. PTau181 showed the highest area under the curve of 0.85 for the discrimination of SCD and DAT with a sensitivity of 80% and a specificity of 79% at a cut-off of 12.2 pg/mL. Age influenced Ass42, Ass40, and NFL concentrations. Conclusion: Plasma pTau181 and NFL, as well as the ratios Ass42/Ass40 and pTau181/Ass42, are biomarkers, which can differentiate diagnostic groups in a memory clinic setting outside of research studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gerards, Michelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Ann-Katrin UNSPECIFIED orcid.org/0000-0002-1920-0198 UNSPECIFIED Meiberth, Dix UNSPECIFIED UNSPECIFIED UNSPECIFIED Rostamzadeh, Ayda UNSPECIFIED orcid.org/0000-0001-5189-134X UNSPECIFIED Vehreschild, Jorg Janne UNSPECIFIED orcid.org/0000-0002-5446-7170 UNSPECIFIED Wingen-Heimann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannis, Wibke UNSPECIFIED orcid.org/0000-0002-2886-7306 UNSPECIFIED Adami, Pamela Martino UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Karikari, Thomas K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ashton, Nicholas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zetterberg, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Blennow, Kaj UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED orcid.org/0000-0002-9335-9594 UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693013
DOI:	10.1159/000524390
Journal or Publication Title:	Dement. Geriatr. Cogn. Disord.
Volume:	51
Number:	2
Page Range:	S. 182 - 193
Date:	2022
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1421-9824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASSAY; PERFORMANCE Multiple languages Geriatrics & Gerontology; Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69301