Universität zu Köln

Cannatelli, Rosanna ORCID: 0000-0001-8378-0724, Bazarova, Alina, Furfaro, Federica, Parigi, Tommaso Lorenzo ORCID: 0000-0002-3398-0231, Zardo, Davide, Nardone, Olga Maria, Spaggiari, Paola ORCID: 0000-0003-2905-1736, Villanacci, Vincenzo, Cadei, Moris, Labarile, Nunzia, Smith, Samuel Charles Lloyd, Danese, Silvio, Ghosh, Subrata and Iacucci, Marietta (2022). Reproducibility of the electronic chromoendoscopy PICaSSO score (Paddington International Virtual ChromoendoScopy ScOre) in ulcerative colitis using multiple endoscopic platforms: a prospective multicenter international study (with video). Gastrointest. Endosc., 96 (1). S. 73 - 84. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-6779

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Abstract

Background and Aims: Endoscopic and histologic remission (HR) are key therapeutic targets in the management of ulcerative colitis (UC). The aim of this study was to evaluate the reproducibility of the Paddington International virtual ChromoendoScopy ScOre (PICaSSO), a virtual chromoendoscopy score originally validated by use of the iSCAN platform, with the narrow-band imaging (NBI), linked-color imaging (LCI), and blue-laser imaging (BLI) platforms. Methods: We evaluated endoscopic activity using the Mayo Endoscopic Score (MES), the Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and PICaSSO in 159 UC patients (78 NBI and 81 BLI/LCI) who underwent colonoscopy in 2 tertiary referral centers. HR was defined by the Robarts Histopathology Index (RHI) and the Nancy Histologic Index (NHI). Receiver operating characteristic curves were plotted to evaluate endoscopic scores for the prediction of HR. Intraclass correlation coefficients (ICC) between endoscopists were evaluated. Results: PICaSSO had an ICC of 0.825 when the NBI and BLI/LCI cohorts were combined, higher than MES and UCEIS. The correlation between PICaSSO and RHI and NHI was 0.83 and 0.79 in the NBI cohort and between 0.63 and 0.65 in LCI/BLI. In the NBI cohort, the accuracy of MES, UCEIS, and PICaSSO was 0.936, 0.897, and 0.808 for HR measured by RHI and 0.897, 0.885, and 0.821 by NHI, respectively. In the BLI/LCI cohort, the accuracy of MES, UCEIS, LCI PICaSSO and BLI PICaSSO was 0.765, 0.778, 0.827, and 0.79 to predict HR with RHI and NHI, respectively. Conclusions: The PICaSSO score can be consistently and accurately reproduced with NBI and LCI/BLI and therefore can be applied to all virtual electronic chromoendoscopy platforms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cannatelli, Rosanna UNSPECIFIED orcid.org/0000-0001-8378-0724 UNSPECIFIED Bazarova, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Furfaro, Federica UNSPECIFIED UNSPECIFIED UNSPECIFIED Parigi, Tommaso Lorenzo UNSPECIFIED orcid.org/0000-0002-3398-0231 UNSPECIFIED Zardo, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Nardone, Olga Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Spaggiari, Paola UNSPECIFIED orcid.org/0000-0003-2905-1736 UNSPECIFIED Villanacci, Vincenzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Cadei, Moris UNSPECIFIED UNSPECIFIED UNSPECIFIED Labarile, Nunzia UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Samuel Charles Lloyd UNSPECIFIED UNSPECIFIED UNSPECIFIED Danese, Silvio UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghosh, Subrata UNSPECIFIED UNSPECIFIED UNSPECIFIED Iacucci, Marietta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693372
DOI:	10.1016/j.gie.2022.02.012
Journal or Publication Title:	Gastrointest. Endosc.
Volume:	96
Number:	1
Page Range:	S. 73 - 84
Date:	2022
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-6779
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HISTOLOGICAL REMISSION; CLINICAL RELAPSE; RELIABILITY; THERAPY Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69337