Patil, Paurnima, Hillebrecht, Sina, Chteinberg, Emil ORCID: 0000-0002-9231-9291, Lopez, Cristina, Toprak, Umut H., Seufert, Julian, Bernhart, Stephan H., Kretzmer, Helene ORCID: 0000-0002-0723-4980, Bergmann, Anke K., Bens, Susanne, Hoegel, Josef, Mueller, Annika, Jebaraj, Billy Michael, Schrader, Alexandra, Johansson, Patricia, Costa, Dolors, Schlesner, Matthias, Duerig, Jan, Herling, Marco, Campo, Elias, Stilgenbauer, Stephan, Wiehle, Laura ORCID: 0000-0001-6081-3925 and Siebert, Reiner (2022). T-cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level. Gene Chromosomes Cancer, 61 (7). S. 432 - 437. HOBOKEN: WILEY. ISSN 1098-2264

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Abstract

Deregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111 miRNAs were differentially expressed in T-PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T-PLL.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Patil, PaurnimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillebrecht, SinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chteinberg, EmilUNSPECIFIEDorcid.org/0000-0002-9231-9291UNSPECIFIED
Lopez, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toprak, Umut H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seufert, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernhart, Stephan H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretzmer, HeleneUNSPECIFIEDorcid.org/0000-0002-0723-4980UNSPECIFIED
Bergmann, Anke K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bens, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoegel, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jebaraj, Billy MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrader, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johansson, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, DolorsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlesner, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duerig, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herling, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campo, EliasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stilgenbauer, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiehle, LauraUNSPECIFIEDorcid.org/0000-0001-6081-3925UNSPECIFIED
Siebert, ReinerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-693719
DOI: 10.1002/gcc.23034
Journal or Publication Title: Gene Chromosomes Cancer
Volume: 61
Number: 7
Page Range: S. 432 - 437
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1098-2264
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EXPRESSION; GENE; MECHANISMS; MUTATIONSMultiple languages
Oncology; Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69371

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