Universität zu Köln

Thielen, J-W, Mueller, B. W., Chang, D-, I, Krug, A., Mehl, S., Rapp, A., Walter, H., Winterer, G., Vogeley, K., Klingberg, S., Wagner, M. and Kircher, T. (2022). Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance. Eur. Arch. Psych. Clin. Neurosci., 272 (7). S. 1241 - 1252. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Schizophrenia has been associated with structural brain abnormalities and cognitive deficits that partly change during the course of illness. In the present study, cortical thickness in five subregions of the cingulate gyrus was assessed in 44 patients with schizophrenia-spectrum disorder and 47 control persons and related to illness duration and memory capacities. In the patients group, cortical thickness was increased in the posterior part of the cingulate gyrus and related to illness duration whereas cortical thickness was decreased in anterior parts unrelated to illness duration. In contrast, cortical thickness was related to episodic and working memory performance only in the anterior but not posterior parts of the cingulate gyrus. Our finding of a posterior cingulate increase may point to either increased parietal communication that is accompanied by augmented neural plasticity or to effects of altered neurodegenerative processes in schizophrenia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thielen, J-W UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, B. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, D-, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehl, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rapp, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Winterer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kircher, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693761
DOI:	10.1007/s00406-021-01369-2
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	272
Number:	7
Page Range:	S. 1241 - 1252
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GRAY-MATTER ABNORMALITIES; POSTERIOR CINGULATE; CEREBRAL-CORTEX; DECISION-MAKING; WORKING-MEMORY; 1ST EPISODE; DIGIT SPAN; AGE; ONSET; MRI Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69376