Universität zu Köln

Raichle, Claudia ORCID: 0000-0003-4452-0369, Borgmann, Stefan, Bausewein, Claudia, Rieg, Siegbert, Jakob, Carolin E. M., Simon, Steffen T., Tometten, Lukas, Vehreschild, Jorg Janne ORCID: 0000-0002-5446-7170, Leisse, Charlotte, Erber, Johanna, Stecher, Melanie, Pauli, Berenike, Ruethrich, Maria Madeleine, Pilgram, Lisa ORCID: 0000-0002-1020-0650, Hanses, Frank, Isberner, Nora, Hower, Martin, Degenhardt, Christian, Hertenstein, Bernd, Vehreschild, Maria J. G. T., Roemmele, Christoph and Jung, Norma (2022). Hospitalized patients dying with SARS-CoV-2 infection-An analysis of patient characteristics and management in ICU and general ward of the LEOSS registry. PLoS One, 17 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background COVID-19 is a severe disease with a high need for intensive care treatment and a high mortality rate in hospitalized patients. The objective of this study was to describe and compare the clinical characteristics and the management of patients dying with SARS-CoV-2 infection in the acute medical and intensive care setting. Methods Descriptive analysis of dying patients enrolled in the Lean European Open Survey on SARS-CoV-2 Infected Patients (LEOSS), a non-interventional cohort study, between March 18 and November 18, 2020. Symptoms, comorbidities and management of patients, including palliative care involvement, were compared between general ward and intensive care unit (ICU) by univariate analysis. Results 580/4310 (13%) SARS-CoV-2 infected patients died. Among 580 patients 67% were treated on ICU and 33% on a general ward. The spectrum of comorbidities and symptoms was broad with more comorbidities (>= four comorbidities: 52% versus 25%) and a higher age distribution (>65 years: 98% versus 70%) in patients on the general ward. 69% of patients were in an at least complicated phase at diagnosis of the SARS-CoV-2 infection with a higher proportion of patients in a critical phase or dying the day of diagnosis treated on ICU (36% versus 11%). While most patients admitted to ICU came from home (71%), patients treated on the general ward came likewise from home and nursing home (44% respectively) and were more frequently on palliative care before admission (29% versus 7%). A palliative care team was involved in dying patients in 15%. Personal contacts were limited but more often documented in patients treated on ICU (68% versus 47%). Conclusion Patients dying with SARS-CoV-2 infection suffer from high symptom burden and often deteriorate early with a demand for ICU treatment. Therefor a demand for palliative care expertise with early involvement seems to exist.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Raichle, Claudia UNSPECIFIED orcid.org/0000-0003-4452-0369 UNSPECIFIED Borgmann, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bausewein, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieg, Siegbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakob, Carolin E. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Steffen T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tometten, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Jorg Janne UNSPECIFIED orcid.org/0000-0002-5446-7170 UNSPECIFIED Leisse, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Erber, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Stecher, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauli, Berenike UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruethrich, Maria Madeleine UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilgram, Lisa UNSPECIFIED orcid.org/0000-0002-1020-0650 UNSPECIFIED Hanses, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Isberner, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Hower, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Degenhardt, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hertenstein, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Maria J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roemmele, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Norma UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693790
DOI:	10.1371/journal.pone.0271822
Journal or Publication Title:	PLoS One
Volume:	17
Number:	7
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69379