Universität zu Köln

Eller, Kathrin ORCID: 0000-0002-6214-5008, Knoebl, Paul ORCID: 0000-0002-7909-7225, Bakkaloglu, Sevcan A., Menne, Jan J., Brinkkoetter, Paul T., Grandt, Leonie, Thiem, Ursula, Coppo, Paul, Scully, Marie and Haller, Maria C. ORCID: 0000-0003-4635-6291 (2022). European Renal Best Practice endorsement of guidelines for diagnosis and therapy of thrombotic thrombocytopaenic purpura published by the International Society on Thrombosis and Haemostasis A European Renal Best Practice (ERBP) endorsement of ISTH Guidelines for Treatment of Thrombotic Thrombocytopaenic Purpura (TTP) with some refinements for Europe. Nephrol. Dial. Transplant., 37 (7). S. 1229 - 1235. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2385

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Abstract

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that is caused by severe ADAMTS-13 deficiency. Immune-mediated TTP develops due to autoantibodies against ADAMTS-13, whereas congenital TTP is caused by mutations in the ADAMTS13 gene. Diagnostic possibilities and treatment options in TTP have emerged in recent years, which prompted the International Society on Thrombosis and Haemostasis (ISTH) to publish clinical practice guidelines for the diagnosis and treatment of TTP in 2020. In this article, the European Renal Best Practice Working Group endorsed the ISTH guidelines and emphasizes a number of considerations, including the importance of rapid ADAMTS-13 activity testing, the use of rituximab and anti-von Willebrand factor therapies such as caplacizumab, that enhance the clinical applicability of the guidelines in Europe.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eller, Kathrin UNSPECIFIED orcid.org/0000-0002-6214-5008 UNSPECIFIED Knoebl, Paul UNSPECIFIED orcid.org/0000-0002-7909-7225 UNSPECIFIED Bakkaloglu, Sevcan A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Menne, Jan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkkoetter, Paul T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandt, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiem, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Coppo, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Scully, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Haller, Maria C. UNSPECIFIED orcid.org/0000-0003-4635-6291 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693880
DOI:	10.1093/ndt/gfac034
Journal or Publication Title:	Nephrol. Dial. Transplant.
Volume:	37
Number:	7
Page Range:	S. 1229 - 1235
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2385
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RITUXIMAB; PROPHYLAXIS; CONSENSUS; REMISSION Multiple languages Transplantation; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69388