Universität zu Köln

Kruger, S. F., Lohneis, A., Abendroth, A., Berger, A. W., Ettrich, T. J., Waidmann, O., Kapp, M., Steiner, B., Kumbrink, J., Reischer, A., Haas, M., Westphalen, C. B., Zhang, D., Miller-Phillips, L., Burger, P. J., Kobold, S., Werner, J., Subklewe, M., Von Bergwelt-Baildon, M., Kunzmann, V, Seufferlein, T., Siveke, J. T., Sinn, M., Heinemann, V, Ormanns, S. and Boeck, S. (2022). Prognosis and tumor biology of pancreatic cancer patients with isolated lung metastases: translational results from the German multicenter AIO-YMO-PAK-0515 study. ESMO Open, 7 (1). AMSTERDAM: ELSEVIER. ISSN 2059-7029

Full text not available from this repository.

Abstract

Background: Pulmonary metastasis (M1-PUL) as first site of dissemination in pancreatic ductal adenocarcinoma (PDAC) is a rare event and may define a distinct biological subgroup. Patients and methods: Arbeitsgemeinschaft Internistische Onkologie-Young Medical Oncologists-Pankreas-0515 study (AIO-YMO-PAK-0515) was a retrospective German multicenter study investigating clinical and molecular characteristics of M1-PUL PDAC patients; 115 M1-PUL PDAC patients from 7 participating centers were included. Clinical characteristics and potential prognostic factors were defined within the M1-PUL cohort. Archival tumor samples were analyzed for Her2/neu, HNF1A and KRT81 expression. Additionally, messenger RNA (mRNA) expression analysis (using a 770-gene immune profiling panel) was carried out in the M1-PUL and in a control cohort (M1-ANY). Results: Median overall survival in the entire M1-PUL cohort was 20 months; the most favorable prognosis (median survival: 28 months) was observed in the subgroup of 66 PDAC patients with metachronous lung metastases after previous curative-intent surgery. The number of metastatic lesions, uni- or bilateral lung involvement as well as metastasectomy were identified as potential prognostic factors. Her2/neu expression and PDAC subtyping (by HNF1A and KRT81) did not differ between the M1-PUL and the M1-ANY cohort. mRNA expression analysis revealed significant differentially expressed genes between both cohorts: CD63 and LAMP1 were among the top 20 differentially expressed genes and were identified as potential mediators of organotropism and favorable survival outcome of M1-PUL patients. Conclusion: M1-PUL represents a clinically favorable cohort in PDAC patients. Site of relapse might already be predetermined at the time of surgery and could potentially be predicted by gene expression profiling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kruger, S. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohneis, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abendroth, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, A. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ettrich, T. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Waidmann, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kapp, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiner, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kumbrink, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reischer, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Westphalen, C. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Miller-Phillips, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burger, P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobold, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Subklewe, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Von Bergwelt-Baildon, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunzmann, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Seufferlein, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Siveke, J. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinn, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinemann, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Ormanns, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boeck, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693922
DOI:	10.1016/j.esmoop.2022.100388
Journal or Publication Title:	ESMO Open
Volume:	7
Number:	1
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2059-7029
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DUCTAL ADENOCARCINOMA; PULMONARY METASTASES; PRIMARY RECURRENCE; SUBTYPES; SURVIVAL; THERAPY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69392