Xanthopoulou, Kyriaki ORCID: 0000-0001-8591-8184, Imirzalioglu, Can, Walker, Sarah, V, Behnke, Michael, Dinkelacker, Ariane G., Eisenbeis, Simone, Gastmeier, Petra, Goelz, Hanna, Kaeding, Nadja, Kern, Winfried, V, Kola, Axel, Kramme, Evelyn, Lucassen, Kai, Mischnik, Alexander, Peter, Silke, Rohde, Anna M., Rupp, Jan ORCID: 0000-0001-8722-1233, Tacconelli, Evelina, Tobys, David, Vehreschild, Maria J. G. T., Wille, Julia, Seifert, Harald and Higgins, Paul G. (2022). Surveillance and Genomic Analysis of Third-Generation Cephalosporin-Resistant and Carbapenem-Resistant Klebsiella pneumoniae Complex in Germany. Antibiotics-Basel, 11 (10). BASEL: MDPI. ISSN 2079-6382

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Abstract

To analyse the epidemiology and population structure of third-generation cephalosporin-resistant (3GCR) and carbapenem-resistant (CR) Klebsiella pneumoniae complex isolates, patients were screened for rectal colonisation with 3GCR/CR K. pneumoniae complex on admission to six German university hospitals (2016-2019). Also collected were 3GCR/CR and susceptible K. pneumoniae isolates from patients with bloodstream infections (2016-2018). Whole-genome sequencing was performed followed by multilocus sequencing typing (MLST), core-genome MLST, and resistome and virulome analysis. The admission prevalence of 3GCR K. pneumoniae complex isolates during the 4-year study period was 0.8%, and 1.0 bloodstream infection per 1000 patient admissions was caused by K. pneumoniae complex (3GCR prevalence, 15.1%). A total of seven K. pneumoniae complex bloodstream isolates were CR (0.8%). The majority of colonising and bloodstream 3GCR isolates were identified as K. pneumoniae, 96.7% and 98.8%, respectively; the remainder were K. variicola and K. quasipneumoniae. cgMLST showed a polyclonal population of colonising and bloodstream isolates, which was also reflected by MLST and virulome analysis. CTX-M-15 was the most prevalent extended-spectrum beta-lactamase, and 29.7% of the colonising and 48.8% of the bloodstream isolates were high-risk clones. The present study provides an insight into the polyclonal 3GCR K. pneumoniae population in German hospitals.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Xanthopoulou, KyriakiUNSPECIFIEDorcid.org/0000-0001-8591-8184UNSPECIFIED
Imirzalioglu, CanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, Sarah, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behnke, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinkelacker, Ariane G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisenbeis, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gastmeier, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goelz, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaeding, NadjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kern, Winfried, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kola, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kramme, EvelynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lucassen, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mischnik, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peter, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rohde, Anna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rupp, JanUNSPECIFIEDorcid.org/0000-0001-8722-1233UNSPECIFIED
Tacconelli, EvelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tobys, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wille, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, Paul G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-694202
DOI: 10.3390/antibiotics11101286
Journal or Publication Title: Antibiotics-Basel
Volume: 11
Number: 10
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2079-6382
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIMICROBIAL RESISTANCE; MOLECULAR EPIDEMIOLOGY; BETA-LACTAMASES; EMERGENCE; VIRULENCE; ENTEROBACTERIACEAE; COLONIZATION; DIVERSITY; VARIICOLA; BACTERIAMultiple languages
Infectious Diseases; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69420

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