Schmidbauer, Moritz L., Ferse, Caroline, Salih, Farid ORCID: 0000-0003-1114-3181, Klingner, Carsten ORCID: 0000-0001-8815-3391, Musleh, Rita, Kunst, Stefan, Wittstock, Matthias, Neumann, Bernhard, Schebesch, Karl-Michael, Boesel, Julian, Godau, Jana, Lochner, Piergiorgio ORCID: 0000-0002-2101-6066, Adam, Elisabeth H., Jahnke, Kolja, Knier, Benjamin ORCID: 0000-0003-4187-9472, Schirotzek, Ingo, Muellges, Wolfgang, Notz, Quirin ORCID: 0000-0002-4042-4436, Dengl, Markus, Gueldner, Andreas, Onur, Oezguer A., Garcia Borrega, Jorge ORCID: 0000-0003-1326-1560, Dimitriadis, Konstantinos and Guenther, Albrecht (2022). COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis. J. Clin. Med., 11 (3). BASEL: MDPI. ISSN 2077-0383

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Abstract

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological subtypes, and clinical characteristics of intracranial hemorrhage (ICH) in coronavirus disease (COVID-19) patients. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the literature by screening the PubMed database and included patients diagnosed with COVID-19 and concomitant ICH. We performed a pooled analysis, including a prospectively collected cohort of critically ill COVID-19 patients with ICH, as part of the PANDEMIC registry (Pooled Analysis of Neurologic Disorders Manifesting in Intensive Care of COVID-19). Results: Our literature review revealed a total of 217 citations. After the selection process, 79 studies and a total of 477 patients were included. The median age was 58.8 years. A total of 23.3% of patients experienced the critical stage of COVID-19, 62.7% of patients were on anticoagulation and 27.5% of the patients received ECMO. The prevalence of ICH was at 0.85% and the mortality at 52.18%, respectively. Conclusion: ICH in COVID-19 patients is rare, but it has a very poor prognosis. Different subtypes of ICH seen in COVID-19, support the assumption of heterogeneous and multifaceted pathomechanisms contributing to ICH in COVID-19. Further clinical and pathophysiological investigations are warranted to resolve the conflict between thromboembolic and hemorrhagic complications in the future.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmidbauer, Moritz L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferse, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salih, FaridUNSPECIFIEDorcid.org/0000-0003-1114-3181UNSPECIFIED
Klingner, CarstenUNSPECIFIEDorcid.org/0000-0001-8815-3391UNSPECIFIED
Musleh, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kunst, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittstock, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumann, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schebesch, Karl-MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boesel, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Godau, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lochner, PiergiorgioUNSPECIFIEDorcid.org/0000-0002-2101-6066UNSPECIFIED
Adam, Elisabeth H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jahnke, KoljaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knier, BenjaminUNSPECIFIEDorcid.org/0000-0003-4187-9472UNSPECIFIED
Schirotzek, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muellges, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Notz, QuirinUNSPECIFIEDorcid.org/0000-0002-4042-4436UNSPECIFIED
Dengl, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gueldner, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onur, Oezguer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia Borrega, JorgeUNSPECIFIEDorcid.org/0000-0003-1326-1560UNSPECIFIED
Dimitriadis, KonstantinosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guenther, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-694227
DOI: 10.3390/jcm11030605
Journal or Publication Title: J. Clin. Med.
Volume: 11
Number: 3
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2077-0383
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EXTRACORPOREAL MEMBRANE-OXYGENATION; INFECTIONMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69422

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