Universität zu Köln

Butter, Rogier ORCID: 0000-0002-4277-6814, Hondelink, Liesbeth M., van Elswijk, Lisette, Blaauwgeers, Johannes L. G., Bloemena, Elisabeth ORCID: 0000-0002-0221-9538, Britstra, Rieneke, Bulkmans, Nicole, van Gulik, Anna Lena, Monkhorst, Kim, de Rooij, Mathilda J., Slavujevic-Letic, Ivana, Smit, Vincent T. H. B. M., Speel, Ernst-Jan M., Thunnissen, Erik, von der Thusen, Jan H., Timens, Wim ORCID: 0000-0002-4146-6363, van de Vijver, Marc J., Yick, David C. Y., Zwinderman, Aeilko H., Cohen, Danielle, 't Hart, Nils A. and Radonic, Teodora ORCID: 0000-0002-6015-5202 (2022). The impact of a pathologist's personality on the interobserver variability and diagnostic accuracy of predictive PD-L1 immunohistochemistry in lung cancer. Lung Cancer, 166. S. 143 - 150. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8332

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Abstract

Objectives: Programmed death-ligand 1 (PD-L1) is the only approved predictive biomarker for immunotherapy in non-small cell lung cancer (NSCLC). However, predictive PD-L1 immunohistochemistry is subject to interobserver variability. We hypothesized that a pathologist's personality influences the interobserver variability and diagnostic accuracy of PD-L1 immunoscoring.& nbsp;Materials and Methods: Seventeen pathologists performed PD-L1 immunoscoring on 50 resected NSCLC tumors in three categories (< 1%;1-49%;>= 50%). Also, the pathologists completed a certified personality test (NEO-PI-r), assessing five personality traits: neuroticism, extraversion, openness, altruism and conscientiousness.& nbsp;Results: The overall agreement among pathologists for a series of 47 tumors was substantial (kappa = 0.63). Of these, 23/47 (49%) tumors were entirely negative or largely positive, resulting in a kappa value of 0.93. The remaining 24/47 (51%) tumors had a PD-L1 score around the cutoff value, generating a kappa value of 0.32. Pathologists with high scores for conscientiousness (careful, diligent) had the least interobserver variability (r = 0.6, p = 0.009). Also, they showed a trend towards higher sensitivity (74% vs. 68%, p = 0.4), specificity (86% vs. 82%, p = 0.3) and percent agreement (83% vs. 79%, p = 0.3), although not significant. In contrast, pathologists with high scores for neuroticism (sensitive, anxious) had significantly lower specificity (80% vs. 87%, p = 0.03) and percent agreement (78% vs. 85%, p = 0.03). Also, a trend towards high interobserver variability (r =-0.3, p = 0.2) and lower sensitivity (68% vs. 74%, p = 0.3) was observed, although not significant. Pathologists with relatively high scores for conscientiousness scored fewer tumors PD-L1 positive at the >= 1% cut-off (r =-0.5, p = 0.03). In contrast, pathologists with relatively high scores for neuroticism score more tumors PD-L1 positive at > 1% (r = 0.6, p = 0.017) and >= 50% cut-offs (r = 0.6, p = 0.009).& nbsp;Conclusions: This study is the first to demonstrate the impact of a pathologist's personality on the interobserver variability and diagnostic accuracy of immunostaining, in the context of PD-L1 in NSCLC. Larger studies are needed for validation of these findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Butter, Rogier UNSPECIFIED orcid.org/0000-0002-4277-6814 UNSPECIFIED Hondelink, Liesbeth M. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Elswijk, Lisette UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaauwgeers, Johannes L. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloemena, Elisabeth UNSPECIFIED orcid.org/0000-0002-0221-9538 UNSPECIFIED Britstra, Rieneke UNSPECIFIED UNSPECIFIED UNSPECIFIED Bulkmans, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED van Gulik, Anna Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Monkhorst, Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED de Rooij, Mathilda J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Slavujevic-Letic, Ivana UNSPECIFIED UNSPECIFIED UNSPECIFIED Smit, Vincent T. H. B. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Speel, Ernst-Jan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thunnissen, Erik UNSPECIFIED UNSPECIFIED UNSPECIFIED von der Thusen, Jan H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timens, Wim UNSPECIFIED orcid.org/0000-0002-4146-6363 UNSPECIFIED van de Vijver, Marc J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yick, David C. Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwinderman, Aeilko H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cohen, Danielle UNSPECIFIED UNSPECIFIED UNSPECIFIED 't Hart, Nils A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Radonic, Teodora UNSPECIFIED orcid.org/0000-0002-6015-5202 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694444
DOI:	10.1016/j.lungcan.2022.03.002
Journal or Publication Title:	Lung Cancer
Volume:	166
Page Range:	S. 143 - 150
Date:	2022
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DECISION-MAKING; CELL; PEMBROLIZUMAB; EXPRESSION; TRAITS Multiple languages Oncology; Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69444