Universität zu Köln

Fisher, Matthew C., Alastruey-Izquierdo, Ana ORCID: 0000-0001-8651-4405, Berman, Judith ORCID: 0000-0002-8577-0084, Bicanic, Tihana, Bignell, Elaine M., Bowyer, Paul, Bromley, Michael ORCID: 0000-0002-7611-0201, Brueggemann, Roger, Garber, Gary, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Gurr, Sarah J., Harrison, Thomas S., Kuijper, Ed, Rhodes, Johanna ORCID: 0000-0002-1338-7860, Sheppard, Donald C., Warris, Adilia ORCID: 0000-0001-6586-3358, White, P. Lewis, Xu, Jianping, Zwaan, Bas ORCID: 0000-0002-8221-4998 and Verweij, Paul E. (2022). Tackling the emerging threat of antifungal resistance to human health. Nat. Rev. Microbiol., 20 (9). S. 557 - 572. BERLIN: NATURE PORTFOLIO. ISSN 1740-1534

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Abstract

Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a period of profound global environmental change and expanding at-risk populations, human-infecting pathogenic fungi are evolving resistance to all licensed systemic antifungal drugs. In this Review, we highlight the main mechanisms of antifungal resistance and explore the similarities and differences between bacterial and fungal resistance to antimicrobial control. We discuss the research and innovation topics that are needed for risk reduction strategies aimed at minimizing the emergence of resistance in pathogenic fungi. These topics include links between the environment and One Health, surveillance, diagnostics, routes of transmission, novel therapeutics and methods to mitigate hotspots for fungal adaptation. We emphasize the global efforts required to steward our existing antifungal armamentarium, and to direct the research and development of future therapies and interventions. The impacts of fungal infections on human health are of increasing concern, and resistance of pathogenic fungi to all licensed systemic antifungals has been documented. In this Review, Fisher, Verweij and colleagues discuss the research and innovation topics that are needed to understand and minimize the occurrence and impact of antifungal resistance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fisher, Matthew C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alastruey-Izquierdo, Ana UNSPECIFIED orcid.org/0000-0001-8651-4405 UNSPECIFIED Berman, Judith UNSPECIFIED orcid.org/0000-0002-8577-0084 UNSPECIFIED Bicanic, Tihana UNSPECIFIED UNSPECIFIED UNSPECIFIED Bignell, Elaine M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bowyer, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Bromley, Michael UNSPECIFIED orcid.org/0000-0002-7611-0201 UNSPECIFIED Brueggemann, Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED Garber, Gary UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED orcid.org/0000-0001-9599-3137 UNSPECIFIED Gurr, Sarah J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Harrison, Thomas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuijper, Ed UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhodes, Johanna UNSPECIFIED orcid.org/0000-0002-1338-7860 UNSPECIFIED Sheppard, Donald C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Warris, Adilia UNSPECIFIED orcid.org/0000-0001-6586-3358 UNSPECIFIED White, P. Lewis UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Jianping UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwaan, Bas UNSPECIFIED orcid.org/0000-0002-8221-4998 UNSPECIFIED Verweij, Paul E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694659
DOI:	10.1038/s41579-022-00720-1
Journal or Publication Title:	Nat. Rev. Microbiol.
Volume:	20
Number:	9
Page Range:	S. 557 - 572
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	1740-1534
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASPERGILLUS-FUMIGATUS; AZOLE RESISTANCE; CRYPTOCOCCAL MENINGITIS; INVASIVE ASPERGILLOSIS; BRONCHOALVEOLAR LAVAGE; VORICONAZOLE; COMBINATION; INFECTION; EMERGENCE; INSIGHTS Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69465