Universität zu Köln

Hird, Emily J., Ohmuro, Noriyuki, Allen, Paul, Moseley, Peter ORCID: 0000-0002-9284-2509, Kempton, Matthew J., Modinos, Gemma, Sachs, Gabriele, van der Gaag, Mark ORCID: 0000-0002-3525-6415, de Haan, Lieuwe, Gadelha, Ary, Bressan, Rodrigo, Barrantes-Vidal, Neus, Ruhrmann, Stephan, Catalan, Ana ORCID: 0000-0002-0418-7904 and McGuire, Philip ORCID: 0000-0003-4381-0532 (2023). Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome. Schizophr. Bull., 49 (2). S. 339 - 350. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Background and hypothesis Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes. Study design At baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning. Study results CHR participants had a lower sensitivity to the task. Logistic regression revealed that a bias towards hearing targets in stimuli was associated with remission status (OR = 0.21, P = 042). Conversely, hearing SIs with uncertain valence at baseline was associated with reduced likelihood of remission (OR = 7.72. P = .007). When we assessed only participants who did not take antipsychotic medication at baseline, the association between hearing SIs with uncertain valence at baseline and remission likelihood remained (OR = 7.61, P = .043) and this variable was additionally associated with a greater likelihood of transition to psychosis (OR = 5.34, P = .029). Conclusions In CHR individuals, a tendency to hear speech in noise, and uncertainty about the affective valence of this speech, is associated with adverse outcomes. This task could be used in a battery of cognitive markers to stratify CHR participants according to subsequent outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hird, Emily J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohmuro, Noriyuki UNSPECIFIED UNSPECIFIED UNSPECIFIED Allen, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Moseley, Peter UNSPECIFIED orcid.org/0000-0002-9284-2509 UNSPECIFIED Kempton, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Modinos, Gemma UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachs, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaag, Mark UNSPECIFIED orcid.org/0000-0002-3525-6415 UNSPECIFIED de Haan, Lieuwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Gadelha, Ary UNSPECIFIED UNSPECIFIED UNSPECIFIED Bressan, Rodrigo UNSPECIFIED UNSPECIFIED UNSPECIFIED Barrantes-Vidal, Neus UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Catalan, Ana UNSPECIFIED orcid.org/0000-0002-0418-7904 UNSPECIFIED McGuire, Philip UNSPECIFIED orcid.org/0000-0003-4381-0532 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694845
DOI:	10.1093/schbul/sbac163
Journal or Publication Title:	Schizophr. Bull.
Volume:	49
Number:	2
Page Range:	S. 339 - 350
Date:	2023
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1745-1701
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIGNAL-DETECTION; ABERRANT SALIENCE; INDIVIDUALS; SCHIZOPHRENIA; HALLUCINATIONS; BIASES; NOISE; ONSET Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69484