Zheng, Boyang, Wang, Mianbo, McKenna, Kerry, Shapiro, Lee, Silver, Richard ORCID: 0000-0002-2038-3278, Csuka, Mary Ellen, van den Hoogen, Frank, Robinson, David, Pauling, John D., Hummers, Laura, Krieg, Thomas, Del Galdo, Francesco, Spiera, Robert, Jones, Niall, Khalidi, Nader, Vacca, Alessandra, de Vries-Bouwstra, Jeska K., Gordon, Jessica and Baron, Murray (2022). Agreement Between Physician Evaluation and the Composite Response Index in Diffuse Cutaneous Systemic Sclerosis. Arthritis Care Res., 74 (11). S. 1806 - 1813. HOBOKEN: WILEY. ISSN 2151-4658

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Abstract

Objective Diffuse cutaneous systemic sclerosis (SSc) is a highly heterogeneous disease. A provisionally approved Composite Response Index in diffuse cutaneous SSc (CRISS) was developed as a 1-year outcome measure for clinical trials. Our goal was to further validate the CRISS by examining agreement between CRISS definitions for improved/non-improved with physicians' evaluation of disease. Methods Patient profiles from a large observational cohort were created for 50 random diffuse cutaneous SSc patients of <5 years disease duration with improved CRISS scores after 1 year and 50 with non-improved CRISS scores. Profiles described disease features used during the initial CRISS development at baseline and at 1 year. Each profile was independently rated by 3 expert physicians. Majority opinion determined whether a patient was improved or not improved, and kappa agreement with the CRISS cutoff of 0.6 was calculated. Results Patients had mean +/- SD disease duration of 2.2 +/- 1.3 years. There was substantial agreement between the physician majority opinion about each case and the CRISS (kappa = 0.76 [95% confidence interval (95% CI) 0.64-0.88]). The agreement between each individual physician opinion and the CRISS was also substantial (kappa = 0.70 [95% CI 0.62-0.78]). All CRISS non-improvers were also rated as non-improved by physician majority; however, 12 CRISS improvers were rated as non-improved by physicians. Conclusion There was substantial agreement between the dichotomous CRISS rating and physician assessment of diffuse cutaneous SSc patients after 1 year. This supports the use of a CRISS cutoff at 0.6 for improvement versus non-improvement, although the CRISS tended to rate more patients as improved than did physicians.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zheng, BoyangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, MianboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McKenna, KerryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shapiro, LeeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silver, RichardUNSPECIFIEDorcid.org/0000-0002-2038-3278UNSPECIFIED
Csuka, Mary EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Hoogen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robinson, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauling, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hummers, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieg, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Galdo, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spiera, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, NiallUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khalidi, NaderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vacca, AlessandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Vries-Bouwstra, Jeska K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gordon, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baron, MurrayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-695024
DOI: 10.1002/acr.24638
Journal or Publication Title: Arthritis Care Res.
Volume: 74
Number: 11
Page Range: S. 1806 - 1813
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2151-4658
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL-TRIALS; DISEASE SEVERITY; RISK-FACTORS; SCLERODERMA; CRISS; MANIFESTATIONS; CLASSIFICATION; INVOLVEMENT; SCOREMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69502

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