Freise, Noemi F., Gliga, Smaranda, Fischer, Johannes ORCID: 0000-0002-2079-1845, Lubke, Nadine, Lutterbeck, Matthias, Scholer, Miriam, Bolke, Edwin, Orth, Hans Martin, Feldt, Torsten, Roemmele, Christoph, Wilke, Dominik, Schneider, Jochen, Wille, Kai, Hohmann, Christian, Strauss, Richard, Hower, Martin, Ruf, Andreas, Schubert, Joerg, Isberner, Nora, Stecher, Melanie, Pilgram, Lisa ORCID: 0000-0002-1020-0650, Vehreschild, Jorg J., Hanses, Frank, Luedde, Tom ORCID: 0000-0002-6288-8821 and Jensen, Bjorn (2022). Convalescent plasma treatment for SARS-CoV-2 infected high-risk patients: a matched pair analysis to the LEOSS cohort. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Establishing the optimal treatment for COVID-19 patients remains challenging. Specifically, immunocompromised and pre-diseased patients are at high risk for severe disease course and face limited therapeutic options. Convalescent plasma (CP) has been considered as therapeutic approach, but reliable data are lacking, especially for high-risk patients. We performed a retrospective analysis of 55 hospitalized COVID-19 patients from University Hospital Duesseldorf (UKD) at high risk for disease progression, in a substantial proportion due to immunosuppression from cancer, solid organ transplantation, autoimmune disease, dialysis. A matched-pairs analysis (1:4) was performed with 220 patients from the Lean European Open Survey on SARS-CoV-2-infected Patients (LEOSS) who were treated or not treated with CP. Both cohorts had high mortality (UKD 41.8%, LEOSS 34.1%). A matched-pairs analysis showed no significant effect on mortality. CP administration before the formation of pulmonary infiltrates showed the lowest mortality in both cohorts (10%), whereas mortality in the complicated phase was 27.8%. CP administration during the critical phase revealed the highest mortality: UKD 60.9%, LEOSS 48.3%. In our cohort of COVID-19 patients with severe comorbidities CP did not significantly reduce mortality in a retrospective matched-pairs analysis. However, our data supports the concept that a reduction in mortality is achievable by early CP administration.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Freise, Noemi F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gliga, SmarandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, JohannesUNSPECIFIEDorcid.org/0000-0002-2079-1845UNSPECIFIED
Lubke, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lutterbeck, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholer, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bolke, EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orth, Hans MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feldt, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roemmele, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilke, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wille, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hohmann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hower, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schubert, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isberner, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilgram, LisaUNSPECIFIEDorcid.org/0000-0002-1020-0650UNSPECIFIED
Vehreschild, Jorg J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanses, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luedde, TomUNSPECIFIEDorcid.org/0000-0002-6288-8821UNSPECIFIED
Jensen, BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-695168
DOI: 10.1038/s41598-022-23200-1
Journal or Publication Title: Sci Rep
Volume: 12
Number: 1
Date: 2022
Publisher: NATURE PORTFOLIO
Place of Publication: BERLIN
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IMMUNOCOMPROMISED PATIENTS; COVID-19; THERAPY; CELLMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69516

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