Patry, Christian ORCID: 0000-0002-1270-6508, Hoecker, Britta, Dello Strologo, Luca, Baumann, Lukas, Grenda, Ryszard, Peruzzi, Licia ORCID: 0000-0002-5704-3867, Oh, Jun, Pape, Lars ORCID: 0000-0002-3635-6418, Weber, Lutz T., Weitz, Marcus ORCID: 0000-0002-1696-5646, Awan, Atif ORCID: 0000-0002-1615-2602, Carraro, Andrea, Zirngibl, Matthias, Hansen, Matthias, Mueller, Dominik, Bald, Martin, Pecqueux, Carine, Krupka, Kai, Fichtner, Alexander, Toenshoff, Burkhard and Nyarangi-Dix, Joanne (2022). Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice. Pediatr. Transplant., 26 (6). HOBOKEN: WILEY. ISSN 1399-3046

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Abstract

Background Preexistent LUTD are considered a hostile environment, which might negatively impact KTx survival. In such cases, surgical reconstruction of the bladder is required. However, there is still disagreement on the optimal timing of the reconstruction procedure. Methods This is a multicenter analysis of data from the CERTAIN Registry. Included were 62 children aged 8.18 +/- 4.90 years, with LUTD. Study endpoints were the duration of initial posttransplant hospitalization, febrile UTIs, and a composite failure endpoint comprising decline of eGFR, graft loss, or death up to 5 years posttransplant. Outcome was compared to matched controls without bladder dysfunction. Results Forty-one patients (66.1%) underwent pretransplant and 14 patients (22.6%) posttransplant reconstruction. Bladder augmentation was performed more frequently in the pretransplant (61%) than in the posttransplant group (21%, p = .013). Outcome in the pre- and posttransplant groups and in the subgroups of patients on pretransplant PD with major bladder surgery either pre- (n = 14) or posttransplant (n = 7) was comparable. Outcomes of the main study cohort and the matched control cohort (n = 119) were comparable during the first 4 years posttransplant; at year 5, there were more events of transplant dysfunction in the study cohort with LUTD than in controls (p = .03). Conclusions This multicenter analysis of the current practice of LUTD reconstruction in pediatric KTx recipients shows that pre- or posttransplant surgical reconstruction of the lower urinary tract is associated with a comparable 5-year outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Patry, ChristianUNSPECIFIEDorcid.org/0000-0002-1270-6508UNSPECIFIED
Hoecker, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dello Strologo, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grenda, RyszardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peruzzi, LiciaUNSPECIFIEDorcid.org/0000-0002-5704-3867UNSPECIFIED
Oh, JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pape, LarsUNSPECIFIEDorcid.org/0000-0002-3635-6418UNSPECIFIED
Weber, Lutz T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weitz, MarcusUNSPECIFIEDorcid.org/0000-0002-1696-5646UNSPECIFIED
Awan, AtifUNSPECIFIEDorcid.org/0000-0002-1615-2602UNSPECIFIED
Carraro, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zirngibl, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bald, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pecqueux, CarineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krupka, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fichtner, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toenshoff, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nyarangi-Dix, JoanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-695390
DOI: 10.1111/petr.14328
Journal or Publication Title: Pediatr. Transplant.
Volume: 26
Number: 6
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1399-3046
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RENAL-TRANSPLANTATION; AUGMENTATION CYSTOPLASTY; BLADDER AUGMENTATION; CHILDREN; OUTCOMES; SAFE; DYSFUNCTION; DIVERSION; REGISTRYMultiple languages
Pediatrics; TransplantationMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69539

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