Galldiks, Norbert, Langen, Karl-Josef, Albert, Nathalie L., Law, Ian, Kim, Michelle M., Villanueva-Meyer, Javier E., Soffietti, Riccardo, Wen, Patrick Y., Weller, Michael ORCID: 0000-0002-1748-174X and Tonn, Joerg C. (2022). Investigational PET tracers in neuro-oncology-What's on the horizon? A report of the PET/RANO group. Neuro-Oncology, 24 (11). S. 1815 - 1827. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

Many studies in patients with brain tumors evaluating innovative PET tracers have been published in recent years, and the initial results are promising. Here, the Response Assessment in Neuro-Oncology (RANO) PET working group provides an overview of the literature on novel investigational PET tracers for brain tumor patients. Furthermore, newer indications of more established PET tracers for the evaluation of glucose metabolism, amino acid transport, hypoxia, cell proliferation, and others are also discussed. Based on the preliminary findings, these novel investigational PET tracers should be further evaluated considering their promising potential. In particular, novel PET probes for imaging of translocator protein and somatostatin receptor overexpression as well as for immune system reactions appear to be of additional clinical value for tumor delineation and therapy monitoring. Progress in developing these radiotracers may contribute to improving brain tumor diagnostics and advancing clinical translational research.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Galldiks, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langen, Karl-JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albert, Nathalie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Law, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Michelle M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villanueva-Meyer, Javier E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soffietti, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wen, Patrick Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDorcid.org/0000-0002-1748-174XUNSPECIFIED
Tonn, Joerg C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-695785
DOI: 10.1093/neuonc/noac131
Journal or Publication Title: Neuro-Oncology
Volume: 24
Number: 11
Page Range: S. 1815 - 1827
Date: 2022
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1523-5866
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITRON-EMISSION-TOMOGRAPHY; SOMATOSTATIN RECEPTOR SUBTYPES; RADIOLABELED AMINO-ACIDS; BRAIN METASTASES; 3'-DEOXY-3'-F-18-FLUOROTHYMIDINE PET; INTEGRIN ALPHA(V)BETA(3); GLIOBLASTOMA-MULTIFORME; CELL-PROLIFERATION; TRYPTOPHAN UPTAKE; MALIGNANT GLIOMAMultiple languages
Oncology; Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69578

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