Universität zu Köln

Kearsley-Fleet, Lianne ORCID: 0000-0003-0377-1575, Klotsche, Jens, van Straalen, Joeri W., Costello, Wendy, D'Angelo, Gianfranco, Giancane, Gabriella, Horneff, Gerd, Klein, Ariane, Laday, Matilda, Lunt, Mark, de Roock, Sytze, Ruperto, Nicolino, Schoemaker, Casper, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Vougiouka, Olga, Wulffraat, Nico M., Hyrich, Kimme L., Minden, Kirsten and Swart, Joost F. (2022). Burden of comorbid conditions in children and young people with juvenile idiopathic arthritis: a collaborative analysis of 3 JIA registries. RHEUMATOLOGY, 61 (6). S. 2524 - 2535. OXFORD: OXFORD UNIV PRESS. ISSN 1462-0332

Full text not available from this repository.

Abstract

Objectives Burden of comorbidities are largely unknown in JIA. From 2000, national and international patient registries were established to monitor biologic treatment, disease activity and adverse events in patients with JIA. The aim of this analysis was to investigate in parallel, for the first time, three of the largest JIA registries in Europe/internationally-UK JIA Biologic Registers (BCRD/BSPAR-ETN), German biologic registers (BiKeR/JuMBO), multinational Pharmachild-to quantify the occurrence of selected comorbidities in patients with JIA. Methods Information on which data the registers collect were compared. Patient characteristics and levels of comorbidity were presented, focussing on four key conditions: uveitis, MAS, varicella, and history of tuberculosis. Incidence rates of these on MTX/biologic therapy were determined. Results 8066 patients were registered into the three JIA registers with similar history of the four comorbidities across the studies; however, varicella vaccination coverage was higher in Germany (56%) vs UK/Pharmachild (16%/13%). At final follow-up, prevalence of varicella infection was lower in Germany (15%) vs UK/Pharmachild (37%/50%). Prevalence of TB (0.1-1.8%) and uveitis (15-19%) was similar across all registers. The proportion of systemic-JIA patients who ever had MAS was lower in Germany (6%) vs UK (15%) and Pharmachild (17%). Conclusion This analysis is the first and largest to investigate the occurrence of four important comorbidities in three JIA registries in Europe and the role of anti-rheumatic drugs. Combined, these three registries represent one of the biggest collection of cases of JIA worldwide and offer a unique setting for future JIA outcome studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kearsley-Fleet, Lianne UNSPECIFIED orcid.org/0000-0003-0377-1575 UNSPECIFIED Klotsche, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED van Straalen, Joeri W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Costello, Wendy UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Angelo, Gianfranco UNSPECIFIED UNSPECIFIED UNSPECIFIED Giancane, Gabriella UNSPECIFIED UNSPECIFIED UNSPECIFIED Horneff, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Ariane UNSPECIFIED UNSPECIFIED UNSPECIFIED Laday, Matilda UNSPECIFIED UNSPECIFIED UNSPECIFIED Lunt, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED de Roock, Sytze UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruperto, Nicolino UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoemaker, Casper UNSPECIFIED UNSPECIFIED UNSPECIFIED Vijatov-Djuric, Gordana UNSPECIFIED UNSPECIFIED UNSPECIFIED Vojinovic, Jelena UNSPECIFIED UNSPECIFIED UNSPECIFIED Vougiouka, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Wulffraat, Nico M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hyrich, Kimme L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Minden, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Swart, Joost F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695828
DOI:	10.1093/rheumatology/keab641
Journal or Publication Title:	RHEUMATOLOGY
Volume:	61
Number:	6
Page Range:	S. 2524 - 2535
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1462-0332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MACROPHAGE ACTIVATION SYNDROME; VARICELLA; HEALTH; VACCINATION Multiple languages Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69582