Witberg, Guy, Landes, Uri, Talmor-Barkan, Yeela, Richter, Ilan ORCID: 0000-0001-9358-0056, Barbanti, Marco ORCID: 0000-0002-4903-5437, Valvo, Roberto, De Backer, Ole, Ooms, Joris F., Islas, Fabian, Marroquin, Luis, Sedaghat, Alexander, Sugiura, Atsushi, Masiero, Giulia, Armario, Xavier ORCID: 0000-0002-4662-0251, Fiorina, Claudia, Arzamendi, Dabit, Santos-Martinez, Sandra, Fernandez-Vazquez, Felipe, Baz, Jose A., Steblovnik, Klemen ORCID: 0000-0003-2099-6389, Mauri, Victor, Adam, Matti, Merdler, Ilan, Hein, Manuel, Ruile, Philipp, Codner, Pablo, Grasso, Carmelo, Branca, Luca, Estevez-Loureiro, Rodrigo ORCID: 0000-0001-5841-5514, Benito-Gonzalez, Tomas, Amat-Santos, Ignacio J., Mylotte, Darren, Bunc, Matjaz, Tarantini, Giuseppe, Nombela-Franco, Luis, Sondergaard, Lars, Van Mieghem, Nicolas M., Finkelstein, Ariel and Kornowski, Ran (2022). Center Valve Preference and Outcomes of Transcatheter Aortic Valve Replacement Insights From the AMTRAC Registry. JACC-Cardiovasc. Interv., 15 (12). S. 1266 - 1275. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-7605

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Abstract

BACKGROUND Data on outcomes of transcatheter aortic valve replacement (TAVR) using balloon-expandable valves (BEVs) or self-expandable valves (SEVs) as well as the impact of center valve preference on these outcomes are limited. OBJECTIVES The aim of this study was to compare outcomes of TAVR procedures using third-generation BEVs and SEVs stratified by center valve preference. METHODS In a multicenter registry (n = 17), 13 centers exhibited valve preference (66.6%-90% of volume) and were included. Outcomes were compared between BEVs and SEVs stratified by center valve preference. RESULTS In total, 7,528 TAVR procedures (3,854 with SEVs and 3,674 with BEVs) were included. The mean age was 81 years, and the mean Society of Thoracic Surgeons score was 5.2. Baseline characteristics were similar between BEVs and SEVs. Need for pacemaker implantation was higher with SEVs at BEV-and SEV-dominant centers (17.8% vs 9.3% [P < 0.001] and 12.7% vs 10.0% [P = 0.036], respectively; HR: 1.51; P for interaction = 0.021), risk for cerebrovascular accident was higher with SEVs at BEV-dominant but not SEV-dominant centers (3.6% vs 1.1% [P < 0.001] and 2.2% vs 1.4% [P = 0.162]; HR: 2.08; P for interaction < 0.01). Aortic regurgitation greater than mild was more frequent with SEVs at BEV-dominant centers and similar with BEVs regardless of center dominance (5.2% vs 2.8% [P < 0.001] and 3.4% vs 3.7% [P = 0.504], respectively). Two-year mortality was higher with SEVs at BEV-dominant centers but not at SEV-dominant centers (21.9% vs 16.9% [P = 0.021] and 16.8% vs 16.5% [P = 0.642], respectively; HR: 1.20; P for interaction = 0.032). CONCLUSIONS Periprocedural outcomes, aortic regurgitation greater than mild, and 2-year mortality are worse when TAVR is performed using SEVs at BEV-dominant centers. Outcomes are similar regardless of valve type at SEV-dominant centers. The present results stress the need to account for this factor when comparing BEV and SEV outcomes. (The Aortic+Mitral Transcatheter [AMTRAC] Valve Registry; NCT04031274) (C) 2022 by the American College of Cardiology Foundation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Witberg, GuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landes, UriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Talmor-Barkan, YeelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, IlanUNSPECIFIEDorcid.org/0000-0001-9358-0056UNSPECIFIED
Barbanti, MarcoUNSPECIFIEDorcid.org/0000-0002-4903-5437UNSPECIFIED
Valvo, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Backer, OleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ooms, Joris F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Islas, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marroquin, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sedaghat, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sugiura, AtsushiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Masiero, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Armario, XavierUNSPECIFIEDorcid.org/0000-0002-4662-0251UNSPECIFIED
Fiorina, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arzamendi, DabitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos-Martinez, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez-Vazquez, FelipeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baz, Jose A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steblovnik, KlemenUNSPECIFIEDorcid.org/0000-0003-2099-6389UNSPECIFIED
Mauri, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adam, MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merdler, IlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruile, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Codner, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grasso, CarmeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Branca, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Estevez-Loureiro, RodrigoUNSPECIFIEDorcid.org/0000-0001-5841-5514UNSPECIFIED
Benito-Gonzalez, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amat-Santos, Ignacio J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mylotte, DarrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bunc, MatjazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tarantini, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nombela-Franco, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sondergaard, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Mieghem, Nicolas M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finkelstein, ArielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornowski, RanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696053
DOI: 10.1016/j.jcin.2022.05.004
Journal or Publication Title: JACC-Cardiovasc. Interv.
Volume: 15
Number: 12
Page Range: S. 1266 - 1275
Date: 2022
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1876-7605
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MITRAL REGURGITATION; IMPLANTATION; TAVR; VOLUME; IMPACTMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69605

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