Rogers, S., Baumert, B., Blanck, O., Boehmer, D., Bostroem, J., Engenhart-Cabillic, R., Ermis, E., Exner, S., Guckenberger, M., Habermehl, D., Hemmatazad, H., Henke, G., Lohaus, F., Lux, S., Mai, S., Minasch, D., Rezazadeh, A., Steffal, C., Temming, S., Wittig, A., Zweifel, C., Riesterer, O. and Combs, S. (2022). Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO). Strahlenther. Onkol., 198 (10). S. 919 - 926. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Purpose Preoperative stereotactic radiosurgery (SRS) of brain metastases may achieve similar local control and better leptomeningeal control rates than postoperative fractionated stereotactic radiotherapy (FSRT) in patients treated with elective metastasectomy. To plan a multicentre trial of preoperative SRS compared with postoperative FSRT, a survey of experts was conducted to determine current practice. Methods A survey with 15 questions was distributed to the DEGRO Radiosurgery and Stereotactic Radiotherapy Working Group. Participants were asked under what circumstances they offered SRS, FSRT, partial and/or whole brain radiotherapy before or after resection of a brain metastasis, as well as the feasibility of preoperative stereotactic radiosurgery and neurosurgical resection within 6 days. Results Of 25 participants from 24 centres, 22 completed 100% of the questions. 24 respondents were radiation oncologists and 1 was a neurosurgeon. All 24 centres have one or more dedicated radiosurgery platform and all offer postoperative FSRT. Preoperative SRS is offered by 4/24 (16.7%) centres, and 9/24 (37.5%) sometimes recommend single-fraction postoperative SRS. Partial brain irradiation is offered by 8/24 (33.3%) centres and 12/24 (50%) occasionally recommend whole-brain irradiation. Two centres are participating in clinical trials of preoperative SRS. SRS techniques and fractionation varied between centres. Conclusion All responding centres currently offer postoperative FSRT after brain metastasectomy. Approximately one third offer single-fraction postoperative SRS and four already perform preoperative SRS. With regard to potential co-investigators, 18 were identified for the PREOP-2 multicentre trial, which will randomise between preoperative SRS and postoperative FSRT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rogers, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumert, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blanck, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehmer, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bostroem, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engenhart-Cabillic, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ermis, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Exner, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guckenberger, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habermehl, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmatazad, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henke, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohaus, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lux, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mai, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minasch, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rezazadeh, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffal, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Temming, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittig, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zweifel, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riesterer, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Combs, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696068
DOI: 10.1007/s00066-022-01991-6
Journal or Publication Title: Strahlenther. Onkol.
Volume: 198
Number: 10
Page Range: S. 919 - 926
Date: 2022
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-099X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MULTICENTER; CAVITYMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69606

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