Schwarzer, Johanna M., Meyhoefer, Inga, Antonucci, Linda A. ORCID: 0000-0002-7919-7402, Kambeitz-Ilankovic, Lana ORCID: 0000-0002-8218-0425, Surmann, Marian, Bienek, Olga, Romer, Georg, Dannlowski, Udo, Hahn, Tim, Korda, Alexandra, Dwyer, Dominic B., Ruef, Anne, Haas, Shalaila S., Rosen, Marlene, Lichtenstein, Theresa, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Kambeitz, Joseph, Salokangas, Raimo K. R., Pantelis, Christos, Schultze-Lutter, Frauke, Meisenzahl, Eva, Brambilla, Paolo, Bertolino, Alessandro, Borgwardt, Stefan, Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Koutsouleris, Nikolaos and Lencer, Rebekka (2022). The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis. Neuropsychopharmacology, 47 (12). S. 2051 - 2061. LONDON: SPRINGERNATURE. ISSN 1740-634X

Full text not available from this repository.

Abstract

Subtle subjective visual dysfunctions (VisDys) are reported by about 50% of patients with schizophrenia and are suggested to predict psychosis states. Deeper insight into VisDys, particularly in early psychosis states, could foster the understanding of basic disease mechanisms mediating susceptibility to psychosis, and thereby inform preventive interventions. We systematically investigated the relationship between VisDys and core clinical measures across three early phase psychiatric conditions. Second, we used a novel multivariate pattern analysis approach to predict VisDys by resting-state functional connectivity within relevant brain systems. VisDys assessed with the Schizophrenia Proneness Instrument (SPI-A), clinical measures, and resting-state fMRI data were examined in recent-onset psychosis (ROP, n = 147), clinical high-risk states of psychosis (CHR, n = 143), recent-onset depression (ROD, n = 151), and healthy controls (HC, n = 280). Our multivariate pattern analysis approach used pairwise functional connectivity within occipital (ON) and frontoparietal (FPN) networks implicated in visual information processing to predict VisDys. VisDys were reported more often in ROP (50.34%), and CHR (55.94%) than in ROD (16.56%), and HC (4.28%). Higher severity of VisDys was associated with less functional remission in both CHR and ROP, and, in CHR specifically, lower quality of life (Qol), higher depressiveness, and more severe impairment of visuospatial constructability. ON functional connectivity predicted presence of VisDys in ROP (balanced accuracy 60.17%, p = 0.0001) and CHR (67.38%, p = 0.029), while in the combined ROP + CHR sample VisDys were predicted by FPN (61.11%, p = 0.006). These large-sample study findings suggest that VisDys are clinically highly relevant not only in ROP but especially in CHR, being closely related to aspects of functional outcome, depressiveness, and Qol. Findings from multivariate pattern analysis support a model of functional integrity within ON and FPN driving the VisDys phenomenon and being implicated in core disease mechanisms of early psychosis states.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schwarzer, Johanna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyhoefer, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonucci, Linda A.UNSPECIFIEDorcid.org/0000-0002-7919-7402UNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDorcid.org/0000-0002-8218-0425UNSPECIFIED
Surmann, MarianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bienek, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dannlowski, UdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahn, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korda, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, Dominic B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruef, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, Shalaila S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtenstein, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-6022-2364UNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolino, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencer, RebekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696119
DOI: 10.1038/s41386-022-01385-3
Journal or Publication Title: Neuropsychopharmacology
Volume: 47
Number: 12
Page Range: S. 2051 - 2061
Date: 2022
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1740-634X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SCHIZOPHRENIA-SPECTRUM DISORDERS; QUALITY-OF-LIFE; PERCEPTUAL ORGANIZATION; BASIC SYMPTOMS; CONNECTIVITY; EXPERIENCES; PREDICTION; ILLUSION; INDIVIDUALS; INFORMATIONMultiple languages
Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69611

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item