Universität zu Köln

Haas, Shalaila S., Doucet, Gaelle E., Antoniades, Mathilde, Modabbernia, Amirhossein, Corcoran, Cheryl M., Kahn, Rene S., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Borgwardt, Stefan ORCID: 0000-0002-5792-3987, Brambilla, Paolo, Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Wood, Stephen J., Salokangas, Raimo K. R., Hietala, Jarmo, Meisenzahl, Eva, Koutsouleris, Nikolaos and Frangou, Sophia (2022). Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function. Schizophr. Res-Cogn., 29. AMSTERDAM: ELSEVIER. ISSN 2215-0013

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Abstract

Objective: Social dysfunction is a major feature of clinical-high-risk states for psychosis (CHR-P). Prior research has identified a neuroanatomical pattern associated with impaired social function outcome in CHR-P. The aim of the current study was to test whether social dysfunction in CHR-P is neurobiologically distinct or in a continuum with the lower end of the normal distribution of individual differences in social functioning. Methods: We used a machine learning classifier to test for the presence of a previously validated brain structural pattern associated with impaired social outcome in CHR-P (CHR-outcome-neurosignature) in the neuroimaging profiles of individuals from two non-clinical samples (total n = 1763) and examined its association with social function, psychopathology and cognition. Results: Although the CHR-outcome-neurosignature could be detected in a subset of the non-clinical samples, it was not associated was adverse social outcomes or higher psychopathology levels. However, participants whose neuroanatomical profiles were highly aligned with the CHR-outcome-neurosignature manifested subtle disadvantage in fluid (PFDR = 0.004) and crystallized intelligence (PFDR = 0.01), cognitive flexibility (PFDR = 0.02), inhibitory control (PFDR = 0.01), working memory (PFDR = 0.0005), and processing speed (PFDR = 0.04). Conclusions: We provide evidence of divergence in brain structural underpinnings of social dysfunction derived from a psychosis-risk enriched population when applied to non-clinical samples. This approach appears promising in identifying brain mechanisms bound to psychosis through comparisons of patient populations to nonclinical samples with the same neuroanatomical profiles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haas, Shalaila S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doucet, Gaelle E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antoniades, Mathilde UNSPECIFIED UNSPECIFIED UNSPECIFIED Modabbernia, Amirhossein UNSPECIFIED UNSPECIFIED UNSPECIFIED Corcoran, Cheryl M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahn, Rene S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, Lana UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgwardt, Stefan UNSPECIFIED orcid.org/0000-0002-5792-3987 UNSPECIFIED Brambilla, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Upthegrove, Rachel UNSPECIFIED orcid.org/0000-0001-8204-5103 UNSPECIFIED Wood, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salokangas, Raimo K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hietala, Jarmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisenzahl, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Frangou, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-696129
DOI:	10.1016/j.scog.2022.100252
Journal or Publication Title:	Schizophr. Res-Cogn.
Volume:	29
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2215-0013
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL HIGH-RISK; ULTRA-HIGH RISK; INDIVIDUALS; OUTCOMES; SCHIZOPHRENIA; NEUROCOGNITION; TRAJECTORIES; TRANSITION; DEPRESSION; PREDICTION Multiple languages Psychiatry; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69612