Stefan, Norbert, Sippel, Katrin, Heni, Martin, Fritsche, Andreas, Wagner, Robert, Jakob, Carolin E. M., Preissl, Hubert, von Werder, Alexander, Khodamoradi, Yascha ORCID: 0000-0001-5972-0967, Borgmann, Stefan, Ruethrich, Maria Madeleine, Hanses, Frank, Haselberger, Martina, Piepel, Christiane, Hower, Martin, vom Dahl, Jurgen, Wille, Kai, Roemmele, Christoph, Vehreschild, Janne, Stecher, Melanie, Solimena, Michele ORCID: 0000-0002-3653-8107, Roden, Michael, Schuermann, Annette, Gallwitz, Baptist, de Angelis, Martin Hrabe ORCID: 0000-0002-7898-2353, Ludwig, David S., Schulze, Matthias B., Jensen, Bjoern Erik Ole and Birkenfeld, Andreas L. ORCID: 0000-0003-1407-9023 (2022). Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry. Front. Med., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-858X

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Abstract

Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18-55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55-27.3)] as older (56-75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10-18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stefan, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sippel, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heni, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fritsche, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakob, Carolin E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preissl, HubertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Werder, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khodamoradi, YaschaUNSPECIFIEDorcid.org/0000-0001-5972-0967UNSPECIFIED
Borgmann, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruethrich, Maria MadeleineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanses, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haselberger, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piepel, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hower, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
vom Dahl, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wille, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roemmele, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Solimena, MicheleUNSPECIFIEDorcid.org/0000-0002-3653-8107UNSPECIFIED
Roden, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuermann, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallwitz, BaptistUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Angelis, Martin HrabeUNSPECIFIEDorcid.org/0000-0002-7898-2353UNSPECIFIED
Ludwig, David S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze, Matthias B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, Bjoern Erik OleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Birkenfeld, Andreas L.UNSPECIFIEDorcid.org/0000-0003-1407-9023UNSPECIFIED
URN: urn:nbn:de:hbz:38-696164
DOI: 10.3389/fmed.2022.875430
Journal or Publication Title: Front. Med.
Volume: 9
Date: 2022
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2296-858X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CORONAVIRUS; HOSPITALIZATION; ASSOCIATIONS; ENGLANDMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69616

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