Universität zu Köln

Knopf, Antje-Christin, Czerska, Katarzyna, Fracchiolla, Francesco, Graeff, Christian, Molinelli, Silvia, Rinaldi, Ilaria, Rucincki, Antoni, Sterpin, Edmond, Stuetzer, Kristin, Trnkova, Petra ORCID: 0000-0002-0347-2981, Zhang, Ye ORCID: 0000-0003-1608-4467, Chang, Jeo Y., Giap, Huan, Liu, Wei B., Schild, Steven E., Simone, Charles B., II, Lomax, Antony J. and Meijers, Arturs ORCID: 0000-0002-3647-6647 (2022). Clinical necessity of multi-image based (4DMIB) optimization for targets affected by respiratory motion and treated with scanned particle therapy - A comprehensive review. Radiother. Oncol., 169. S. 77 - 86. CLARE: ELSEVIER IRELAND LTD. ISSN 1879-0887

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Abstract

4D multi-image-based (4DMIB) optimization is a form of robust optimization where different uncertainty scenarios, due to anatomy variations, are considered via multiple image sets (e.g., 4DCT). In this review, we focused on providing an overview of different 4DMIB optimization implementations, introduced various frameworks to evaluate the robustness of scanned particle therapy affected by breathing motion and summarized the existing evidence on the necessity of using 4DMIB optimization clinically. Expected potential benefits of 4DMIB optimization include more robust and/or interplay-effect-resistant doses for the target volume and organs-at-risk for indications affected by anatomical variations (e.g., breathing, peristalsis, etc.). Although considerable literature is available on the research and technical aspects of 4DMIB, clinical studies are rare and often contain methodological limitations, such as, limited patient number, motion amplitude, motion and delivery time structure considerations, number of repeat CTs, etc. Therefore, the data are not conclusive. In addition, multiple studies have found that robust 3D optimized plans result in dose distributions within the set clinical tolerances and, therefore, are suitable for a treatment of moving targets with scanned particle therapy. We, therefore, consider the clinical necessity of 4DMIB optimization, when treating moving targets with scanned particle therapy, as still to be demonstrated. (c) 2022 The Author(s). Published by Elsevier B.V. Radiotherapy and Oncology 169 (2022) 77-85 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Knopf, Antje-Christin UNSPECIFIED UNSPECIFIED UNSPECIFIED Czerska, Katarzyna UNSPECIFIED UNSPECIFIED UNSPECIFIED Fracchiolla, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeff, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Molinelli, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rinaldi, Ilaria UNSPECIFIED UNSPECIFIED UNSPECIFIED Rucincki, Antoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Sterpin, Edmond UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuetzer, Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Trnkova, Petra UNSPECIFIED orcid.org/0000-0002-0347-2981 UNSPECIFIED Zhang, Ye UNSPECIFIED orcid.org/0000-0003-1608-4467 UNSPECIFIED Chang, Jeo Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giap, Huan UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Wei B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Steven E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simone, Charles B., II UNSPECIFIED UNSPECIFIED UNSPECIFIED Lomax, Antony J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meijers, Arturs UNSPECIFIED orcid.org/0000-0002-3647-6647 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-696334
DOI:	10.1016/j.radonc.2022.02.018
Journal or Publication Title:	Radiother. Oncol.
Volume:	169
Page Range:	S. 77 - 86
Date:	2022
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1879-0887
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSITY-MODULATED PROTON; DOSE RECONSTRUCTION; ORGAN MOTION; ROBUST OPTIMIZATION; TREATMENT PLANS; LUNG; 4D; LIVER; INTERPLAY; RADIOTHERAPY Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69633