Universität zu Köln

Hoenigl, Martin, Seidel, Danila, Carvalho, Agostinho ORCID: 0000-0001-8935-8030, Rudramurthy, Shivaprakash M., Arastehfar, Amir ORCID: 0000-0002-4361-4841, Gangneux, Jean-Pierre ORCID: 0000-0002-4974-5607, Nasir, Nosheen, Bonifaz, Alexandro, Araiza, Javier, Klimko, Nikolai, Serris, Alexandra, Lagrou, Katrien, Meis, Jacques F., Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Perfect, John R., White, P. Lewis and Chakrabarti, Arunaloke (2022). The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries. Lancet Microbe, 3 (7). S. E543 - 10. AMSTERDAM: ELSEVIER. ISSN 2666-5247

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Abstract

Reports of COVID-19-associated mucormycosis have been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes. Patients with diabetes and hyperglycaemia often have an inflammatory state that could be potentiated by the activation of antiviral immunity to SARS-CoV2, which might favour secondary infections. In this Review, we analysed 80 published and unpublished cases of COVID-19-associated mucormycosis. Uncontrolled diabetes, as well as systemic corticosteroid treatment, were present in most patients with COVID-19-associated mucormycosis, and rhino-orbital cerebral mucormycosis was the most frequent disease. Mortality was high at 49%, which was particularly due to patients with pulmonary or disseminated mucormycosis or cerebral involvement. Furthermore, a substantial proportion of patients who survived had life-changing morbidities (eg, loss of vision in 46% of survivors). Our Review indicates that COVID-19-associated mucormycosis is associated with high morbidity and mortality. Diagnosis of pulmonary mucormycosis is particularly challenging, and might be frequently missed in India.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoenigl, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED UNSPECIFIED UNSPECIFIED Carvalho, Agostinho UNSPECIFIED orcid.org/0000-0001-8935-8030 UNSPECIFIED Rudramurthy, Shivaprakash M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arastehfar, Amir UNSPECIFIED orcid.org/0000-0002-4361-4841 UNSPECIFIED Gangneux, Jean-Pierre UNSPECIFIED orcid.org/0000-0002-4974-5607 UNSPECIFIED Nasir, Nosheen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonifaz, Alexandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Araiza, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimko, Nikolai UNSPECIFIED UNSPECIFIED UNSPECIFIED Serris, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Lagrou, Katrien UNSPECIFIED UNSPECIFIED UNSPECIFIED Meis, Jacques F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED orcid.org/0000-0001-9599-3137 UNSPECIFIED Perfect, John R. UNSPECIFIED UNSPECIFIED UNSPECIFIED White, P. Lewis UNSPECIFIED UNSPECIFIED UNSPECIFIED Chakrabarti, Arunaloke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-696486
DOI:	10.1016/S2666-5247(21)00237-8
Journal or Publication Title:	Lancet Microbe
Volume:	3
Number:	7
Page Range:	S. E543 - 10
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2666-5247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVASIVE MOLD INFECTIONS; EPIDEMIOLOGY; PATIENT Multiple languages Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69648