Sanfelici, Rachele, Ruef, Anne, Antonucci, Linda A. ORCID: 0000-0002-7919-7402, Penzel, Nora ORCID: 0000-0003-1624-386X, Sotiras, Aristeidis, Sen Dong, Mark, Urquijo-Castro, Maria, Wenzel, Julian, Kambeitz-Ilankovic, Lana ORCID: 0000-0002-8218-0425, Hettwer, Meike D., Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Chisholm, Katharine ORCID: 0000-0002-0575-0789, Riecher-Rossler, Anita, Falkai, Peter, Pantelis, Christos ORCID: 0000-0002-9565-0238, Salokangas, Raimo K. R., Lencer, Rebekka, Bertolino, Alessandro, Kambeitz, Joseph, Meisenzahl, Eva, Borgwardt, Stefan ORCID: 0000-0002-5792-3987, Brambilla, Paolo, Wood, Stephen J., Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Schultze-Lutter, Frauke, Koutsouleris, Nikolaos and Dwyer, Dominic B. (2022). Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness. Cereb. Cortex, 32 (8). S. 1625 - 1637. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatric illness. We hypothesized that the echoes of such disruptions should be observed within structural gyrification networks in early psychiatric illness that would demonstrate associations with developmentally relevant variables rather than specific psychiatric symptoms. We employed a new data-driven method (Orthogonal Projective Non-Negative Matrix Factorization) to delineate novel gyrification-based networks of structural covariance in 308 healthy controls. Gyrification within the networks was then compared to 713 patients with recent onset psychosis or depression, and at clinical high-risk. Associations with diagnosis, symptoms, cognition, and functioning were investigated using linear models. Results demonstrated 18 novel gyrification networks in controls as verified by internal and external validation. Gyrification was reduced in patients in temporal-insular, lateral occipital, and lateral fronto-parietal networks (p(FDR) < 0.01) and was not moderated by illness group. Higher gyrification was associated with better cognitive performance and lifetime role functioning, but not with symptoms. The findings demonstrated that gyrification can be parsed into novel brain networks that highlight generalized illness effects linked to developmental vulnerability. When combined, our study widens the window into the etiology of psychiatric risk and its expression in adulthood.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sanfelici, RacheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruef, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonucci, Linda A.UNSPECIFIEDorcid.org/0000-0002-7919-7402UNSPECIFIED
Penzel, NoraUNSPECIFIEDorcid.org/0000-0003-1624-386XUNSPECIFIED
Sotiras, AristeidisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sen Dong, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urquijo-Castro, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenzel, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDorcid.org/0000-0002-8218-0425UNSPECIFIED
Hettwer, Meike D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-6022-2364UNSPECIFIED
Chisholm, KatharineUNSPECIFIEDorcid.org/0000-0002-0575-0789UNSPECIFIED
Riecher-Rossler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDorcid.org/0000-0002-9565-0238UNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencer, RebekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolino, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDorcid.org/0000-0002-5792-3987UNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, Dominic B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696576
DOI: 10.1093/cercor/bhab288
Journal or Publication Title: Cereb. Cortex
Volume: 32
Number: 8
Page Range: S. 1625 - 1637
Date: 2022
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1460-2199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENERAL COGNITIVE-ABILITY; CORTICAL GYRIFICATION; STRUCTURAL COVARIANCE; PSYCHOTIC DISORDERS; LOCAL GYRIFICATION; TREATMENT RESPONSE; SURFACE-AREA; ORGANIZATION; SCHIZOPHRENIA; PATTERNSMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69657

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