Horgan, Denis, Curigliano, Giuseppe ORCID: 0000-0003-1781-2518, Riess, Olaf, Hofman, Paul ORCID: 0000-0003-0431-9353, Buettner, Reinhard, Conte, Pierfranco, Cufer, Tanja, Gallagher, William M., Georges, Nadia, Kerr, Keith, Penault-Llorca, Frederique, Mastris, Ken ORCID: 0000-0002-6074-8147, Pinto, Carla, Van Meerbeeck, Jan, Munzone, Elisabetta, Thomas, Marlene, Ujupan, Sonia, Vainer, Gilad W. ORCID: 0000-0002-8828-8138, Velthaus, Janna-Lisa and Andre, Fabrice (2022). Identifying the Steps Required to Effectively Implement Next-Generation Sequencing in Oncology at a National Level in Europe. J. Pers. Med., 12 (1). BASEL: MDPI. ISSN 2075-4426

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Abstract

Next-generation sequencing (NGS) may enable more focused and highly personalized cancer treatment, with the National Comprehensive Cancer Network and European Society for Medical Oncology guidelines now recommending NGS for daily clinical practice for several tumor types. However, NGS implementation, and therefore patient access, varies across Europe; a multi-stakeholder collaboration is needed to establish the conditions required to improve this discrepancy. In that regard, we set up European Alliance for Personalised Medicine (EAPM)-led expert panels during the first half of 2021, including key stakeholders from across 10 European countries covering medical, economic, patient, industry, and governmental expertise. We describe the outcomes of these panels in order to define and explore the necessary conditions for NGS implementation into routine clinical care to enable patient access, identify specific challenges in achieving them, and make short- and long-term recommendations. The main challenges identified relate to the demand for NGS tests (governance, clinical standardization, and awareness and education) and supply of tests (equitable reimbursement, infrastructure for conducting and validating tests, and testing access driven by evidence generation). Recommendations made to resolve each of these challenges should aid multi-stakeholder collaboration between national and European initiatives, to complement, support, and mutually reinforce efforts to improve patient care.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Horgan, DenisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curigliano, GiuseppeUNSPECIFIEDorcid.org/0000-0003-1781-2518UNSPECIFIED
Riess, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofman, PaulUNSPECIFIEDorcid.org/0000-0003-0431-9353UNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conte, PierfrancoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cufer, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallagher, William M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Georges, NadiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerr, KeithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penault-Llorca, FrederiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mastris, KenUNSPECIFIEDorcid.org/0000-0002-6074-8147UNSPECIFIED
Pinto, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Meerbeeck, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munzone, ElisabettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ujupan, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vainer, Gilad W.UNSPECIFIEDorcid.org/0000-0002-8828-8138UNSPECIFIED
Velthaus, Janna-LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andre, FabriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696863
DOI: 10.3390/jpm12010072
Journal or Publication Title: J. Pers. Med.
Volume: 12
Number: 1
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2075-4426
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REAL-WORLD EVIDENCE; HEALTH-CARE; PRECISION MEDICINE; FDA APPROVAL; LUNG-CANCER; CHALLENGES; OPPORTUNITIES; FRAMEWORKS; GENOMICS; IMPACTMultiple languages
Health Care Sciences & Services; Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69686

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