Kleineidam, Luca, Wagner, Michael, Guski, Jannis, Wolfsgruber, Steffen, Miebach, Lisa, Bickel, Horst, Koenig, Hans-Helmut, Weyerer, Siegfried, Luehmann, Dagmar, Kaduszkiewicz, Hanna, Luppa, Melanie ORCID: 0000-0003-3927-6728, Rohr, Susanne, Pentzek, Michael, Wiese, Birgitt, Maier, Wolfgang, Scherer, Martin, Kornhuber, Johannes, Peters, Oliver ORCID: 0000-0003-0568-2998, Frolich, Lutz, Wiltfang, Jens, Lewczuk, Piotr, Huell, Michael, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Jessen, Frank, Riedel-Heller, Steffi G. and Heser, Kathrin . Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co-occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear. Methods Temporal relationships of SCD, DS and memory decline were examined by latent difference score modeling in a high-aged, population-based cohort (N = 3217) and validated using Cox-regression of dementia-conversion. In 334 cognitively unimpaired SCD-patients from memory-clinics, we examined the association of DS with cognitive decline and with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Results In the population-based cohort, SCD preceded DS. High DS were associated with increased risk of dementia conversion in individuals with SCD. In SCD-patients from memory-clinics, high DS were associated with greater cognitive decline. CSF Ass42 predicted increasing DS. Discussion SCD typically precedes DS in the evolution to dementia. SCD-patients from memory-clinics with DS may constitute a high-risk group for cognitive decline. Highlights Subjective cognitive decline (SCD) precedes depressive symptoms (DS) as memory declines. Emerging or persistent DS after SCD reports predict dementia. In SCD patients, more amyloid pathology relates to increasing DS. SCD patients with DS are at high risk for symptomatic progression.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guski, JannisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miebach, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickel, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, Hans-HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyerer, SiegfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luehmann, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaduszkiewicz, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luppa, MelanieUNSPECIFIEDorcid.org/0000-0003-3927-6728UNSPECIFIED
Rohr, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pentzek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiese, BirgittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDorcid.org/0000-0003-0568-2998UNSPECIFIED
Frolich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewczuk, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huell, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heser, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696871
DOI: 10.1002/alz.12785
Journal or Publication Title: Alzheimers. Dement.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; MEMORY COMPLAINTS; OLDER-PEOPLE; IMPAIRMENT; ASSOCIATIONS; PERFORMANCE; IMPROVES; RISK; PROGRESSION; ACCURACYMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69687

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