Styczen, Hanna, Maus, Volker ORCID: 0000-0001-5097-2631, Goertz, Lukas, Koehrmann, Martin, Kleinschnitz, Christoph, Fischer, Sebastian, Moehlenbruch, Markus, Muehlen, Iris, Kallmuenzer, Bernd, Dorn, Franziska, Lakghomi, Asadeh, Gawlitza, Matthias, Kaiser, Daniel, Klisch, Joachim, Lobsien, Donald, Rohde, Stefan, Ellrichmann, Gisa, Behme, Daniel, Thormann, Maximilian, Flottmann, Fabian, Winkelmeier, Laurens ORCID: 0000-0002-9103-5983, Gizewski, Elke R., Mayer-Suess, Lukas ORCID: 0000-0002-2856-0101, Boeckh-Behrens, Tobias, Riederer, Isabelle, Klingebiel, Randolf, Berger, Bjoern, Schlunz-Hendann, Martin, Grieb, Dominik, Khanafer, Ali, de Rochemont, Richard du Mesnil, Arendt, Christophe, Altenbernd, Jens, Schlump, Jan-Ulrich, Ringelstein, Adrian, Sanio, Vivian Jean Marcel, Loehr, Christian, Dahlke, Agnes Maria, Brockmann, Carolin, Reder, Sebastian, Sure, Ulrich, Li, Yan, Muehl-Benninghaus, Ruben, Rodt, Thomas, Kallenberg, Kai, Durutya, Alexandru, Elsharkawy, Mohamed, Stracke, Paul, Schumann, Mathias Gerhard, Bock, Alexander, Nikoubashman, Omid, Wiesmann, Martin, Henkes, Hans, Mosimann, Pascal J., Chapot, Rene, Forsting, Michael and Deuschl, Cornelius (2022). Mechanical thrombectomy for acute ischemic stroke in COVID-19 patients: multicenter experience in 111 cases. J. NeuroInterventional Surg., 14 (9). S. 858 - 864. LONDON: BMJ PUBLISHING GROUP. ISSN 1759-8486

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Abstract

Background Data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in patients with COVID-19 is limited. Addressing this subject, we report our multicenter experience. Methods A retrospective cohort study was performed of consecutive acute stroke patients with COVID-19 infection treated with MT at 26 tertiary care centers between January 2020 and November 2021. Baseline demographics, angiographic outcome and clinical outcome evaluated by the modified Rankin Scale (mRS) at discharge and 90 days were noted. Results We identified 111 out of 11 365 (1%) patients with acute or subsided COVID-19 infection who underwent MT due to LVO. Cardioembolic events were the most common etiology for LVO (38.7%). Median baseline National Institutes of Health Stroke Scale score and Alberta Stroke Program Early CT Score were 16 (IQR 11.5-20) and 9 (IQR 7-10), respectively. Successful reperfusion (mTICI >= 2b) was achieved in 97/111 (87.4%) patients and 46/111 (41.4%) patients were reperfused completely. The procedure-related complication rate was 12.6% (14/111). Functional independence was achieved in 20/108 (18.5%) patients at discharge and 14/66 (21.2%) at 90 days follow-up. The in-hospital mortality rate was 30.6% (33/108). In the subgroup analysis, patients with severe acute COVID-19 infection requiring intubation had a mortality rate twice as high as patients with mild or moderate acute COVID-19 infection. Acute respiratory failure requiring ventilation and time interval from symptom onset to groin puncture were independent predictors for an unfavorable outcome in a logistic regression analysis. Conclusion Our study showed a poor clinical outcome and high mortality, especially in patients with severe acute COVID-19 infection undergoing MT due to LVO.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Styczen, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maus, VolkerUNSPECIFIEDorcid.org/0000-0001-5097-2631UNSPECIFIED
Goertz, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehrmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleinschnitz, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moehlenbruch, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muehlen, IrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kallmuenzer, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorn, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lakghomi, AsadehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gawlitza, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klisch, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lobsien, DonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rohde, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellrichmann, GisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behme, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thormann, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flottmann, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winkelmeier, LaurensUNSPECIFIEDorcid.org/0000-0002-9103-5983UNSPECIFIED
Gizewski, Elke R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer-Suess, LukasUNSPECIFIEDorcid.org/0000-0002-2856-0101UNSPECIFIED
Boeckh-Behrens, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riederer, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingebiel, RandolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlunz-Hendann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grieb, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khanafer, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Rochemont, Richard du MesnilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arendt, ChristopheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenbernd, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlump, Jan-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ringelstein, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanio, Vivian Jean MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loehr, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahlke, Agnes MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockmann, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reder, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sure, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, YanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muehl-Benninghaus, RubenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodt, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kallenberg, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Durutya, AlexandruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elsharkawy, MohamedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stracke, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumann, Mathias GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bock, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nikoubashman, OmidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henkes, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosimann, Pascal J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chapot, ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forsting, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, CorneliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-697297
DOI: 10.1136/neurintsurg-2022-018723
Journal or Publication Title: J. NeuroInterventional Surg.
Volume: 14
Number: 9
Page Range: S. 858 - 864
Date: 2022
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1759-8486
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Neuroimaging; SurgeryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69729

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