Universität zu Köln

de Winther, Menno P. J., Back, Magnus ORCID: 0000-0003-0853-5141, Evans, Paul ORCID: 0000-0001-7975-681X, Gomez, Delphine ORCID: 0000-0002-3880-6961, Goncalves, Isabel ORCID: 0000-0002-2935-0181, Jorgensen, Helle F., Koenen, Rory R., Lutgens, Esther ORCID: 0000-0002-2609-5744, Norata, Giuseppe Danilo ORCID: 0000-0002-6081-1257, Osto, Elena, Dib, Lea, Simons, Michael, Stellos, Konstantinos, Yla-Herttuala, Seppo, Winkels, Holger, Bochaton-Piallat, Marie-Luce ORCID: 0000-0001-8408-8932 and Monaco, Claudia (2023). Translational opportunities of single-cell biology in atherosclerosis. Eur. Heart J., 44 (14). S. 1216 - 1231. OXFORD: OXFORD UNIV PRESS. ISSN 1522-9645

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Abstract

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code de Winther, Menno P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Back, Magnus UNSPECIFIED orcid.org/0000-0003-0853-5141 UNSPECIFIED Evans, Paul UNSPECIFIED orcid.org/0000-0001-7975-681X UNSPECIFIED Gomez, Delphine UNSPECIFIED orcid.org/0000-0002-3880-6961 UNSPECIFIED Goncalves, Isabel UNSPECIFIED orcid.org/0000-0002-2935-0181 UNSPECIFIED Jorgensen, Helle F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenen, Rory R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lutgens, Esther UNSPECIFIED orcid.org/0000-0002-2609-5744 UNSPECIFIED Norata, Giuseppe Danilo UNSPECIFIED orcid.org/0000-0002-6081-1257 UNSPECIFIED Osto, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Dib, Lea UNSPECIFIED UNSPECIFIED UNSPECIFIED Simons, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Stellos, Konstantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Yla-Herttuala, Seppo UNSPECIFIED UNSPECIFIED UNSPECIFIED Winkels, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Bochaton-Piallat, Marie-Luce UNSPECIFIED orcid.org/0000-0001-8408-8932 UNSPECIFIED Monaco, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-697466
DOI:	10.1093/eurheartj/ehac686
Journal or Publication Title:	Eur. Heart J.
Volume:	44
Number:	14
Page Range:	S. 1216 - 1231
Date:	2023
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1522-9645
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SMOOTH-MUSCLE-CELLS; MACROPHAGE-LIKE CELLS; MESENCHYMAL TRANSITION; GENE-EXPRESSION; BETA; CLASSIFICATION; IMMUNITY; SUBSETS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69746