Gonzalez-Franquesa, Alba, Gama-Perez, Pau, Kulis, Marta ORCID: 0000-0001-8104-9620, Szczepanowska, Karolina ORCID: 0000-0003-4689-2350, Dahdah, Norma, Moreno-Gomez, Sonia, Latorre-Pellicer, Ana ORCID: 0000-0002-4703-6620, Fernandez-Ruiz, Rebeca, Aguilar-Mogas, Antoni, Hoffman, Anne, Monelli, Erika, Samino, Sara, Miro-Blanch, Joan, Oemer, Gregor, Duran, Xavier, Sanchez-Rebordelo, Estrella, Schneeberger, Marc, Obach, Merce, Montane, Joel ORCID: 0000-0001-9531-9580, Castellano, Giancarlo ORCID: 0000-0002-5715-7733, Chapaprieta, Vicente, Sun, Wenfei ORCID: 0000-0001-5762-6010, Navarro, Lourdes, Prieto, Ignacio ORCID: 0000-0003-0646-6330, Castano, Carlos, Novials, Anna, Gomis, Ramon, Monsalve, Maria, Claret, Marc ORCID: 0000-0001-7766-9296, Graupera, Mariona ORCID: 0000-0003-4608-4185, Soria, Guadalupe ORCID: 0000-0002-8344-0479, Wolfrum, Christian ORCID: 0000-0002-3862-6805, Vendrell, Joan, Fernandez-Veledo, Sonia, Antonio Enriquez, Jose, Carracedo, Angel ORCID: 0000-0003-1085-8986, Carlos Perales, Jose, Nogueiras, Ruben, Herrero, Laura, Trifunovic, Aleksandra ORCID: 0000-0002-5472-3517, Keller, Markus A., Yanes, Oscar, Sales-Pardo, Marta, Guimera, Roger, Blueher, Matthias, Ignacio Martin-Subero, Jose and Garcia-Roves, Pablo M. ORCID: 0000-0002-8371-2067 (2022). Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biol., 54. AMSTERDAM: ELSEVIER. ISSN 2213-2317

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Abstract

Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gonzalez-Franquesa, AlbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gama-Perez, PauUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kulis, MartaUNSPECIFIEDorcid.org/0000-0001-8104-9620UNSPECIFIED
Szczepanowska, KarolinaUNSPECIFIEDorcid.org/0000-0003-4689-2350UNSPECIFIED
Dahdah, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moreno-Gomez, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Latorre-Pellicer, AnaUNSPECIFIEDorcid.org/0000-0002-4703-6620UNSPECIFIED
Fernandez-Ruiz, RebecaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aguilar-Mogas, AntoniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffman, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monelli, ErikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samino, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro-Blanch, JoanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oemer, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duran, XavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Rebordelo, EstrellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneeberger, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obach, MerceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montane, JoelUNSPECIFIEDorcid.org/0000-0001-9531-9580UNSPECIFIED
Castellano, GiancarloUNSPECIFIEDorcid.org/0000-0002-5715-7733UNSPECIFIED
Chapaprieta, VicenteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, WenfeiUNSPECIFIEDorcid.org/0000-0001-5762-6010UNSPECIFIED
Navarro, LourdesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prieto, IgnacioUNSPECIFIEDorcid.org/0000-0003-0646-6330UNSPECIFIED
Castano, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novials, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomis, RamonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monsalve, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claret, MarcUNSPECIFIEDorcid.org/0000-0001-7766-9296UNSPECIFIED
Graupera, MarionaUNSPECIFIEDorcid.org/0000-0003-4608-4185UNSPECIFIED
Soria, GuadalupeUNSPECIFIEDorcid.org/0000-0002-8344-0479UNSPECIFIED
Wolfrum, ChristianUNSPECIFIEDorcid.org/0000-0002-3862-6805UNSPECIFIED
Vendrell, JoanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez-Veledo, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonio Enriquez, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carracedo, AngelUNSPECIFIEDorcid.org/0000-0003-1085-8986UNSPECIFIED
Carlos Perales, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogueiras, RubenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrero, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trifunovic, AleksandraUNSPECIFIEDorcid.org/0000-0002-5472-3517UNSPECIFIED
Keller, Markus A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yanes, OscarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sales-Pardo, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guimera, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blueher, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ignacio Martin-Subero, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Roves, Pablo M.UNSPECIFIEDorcid.org/0000-0002-8371-2067UNSPECIFIED
URN: urn:nbn:de:hbz:38-697533
DOI: 10.1016/j.redox.2022.102353
Journal or Publication Title: Redox Biol.
Volume: 54
Date: 2022
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 2213-2317
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OXIDATIVE STRESS; GENE-EXPRESSION; INFLAMMATION; PROTEOMICS; DIET; DYSFUNCTION; METABOLISM; INCREASES; LINKS; MICEMultiple languages
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69753

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